Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.

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Autores principales:	Zhenzhen Wang, Yan Zhang, Enguo Ju, Zhen Liu, Fangfang Cao, Zhaowei Chen, Jinsong Ren, Xiaogang Qu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/288800d421ff43d08494bee673ac3efb
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spelling	oai:doaj.org-article:288800d421ff43d08494bee673ac3efb2021-12-02T14:41:06ZBiomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors10.1038/s41467-018-05798-x2041-1723https://doaj.org/article/288800d421ff43d08494bee673ac3efb2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05798-xhttps://doaj.org/toc/2041-1723Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.Zhenzhen WangYan ZhangEnguo JuZhen LiuFangfang CaoZhaowei ChenJinsong RenXiaogang QuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhenzhen Wang Yan Zhang Enguo Ju Zhen Liu Fangfang Cao Zhaowei Chen Jinsong Ren Xiaogang Qu Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
description	Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.
format	article
author	Zhenzhen Wang Yan Zhang Enguo Ju Zhen Liu Fangfang Cao Zhaowei Chen Jinsong Ren Xiaogang Qu
author_facet	Zhenzhen Wang Yan Zhang Enguo Ju Zhen Liu Fangfang Cao Zhaowei Chen Jinsong Ren Xiaogang Qu
author_sort	Zhenzhen Wang
title	Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
title_short	Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
title_full	Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
title_fullStr	Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
title_full_unstemmed	Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
title_sort	biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/288800d421ff43d08494bee673ac3efb
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Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

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