In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity

Broadly neutralizing antibodies (bnAbs) against influenza hemagglutinin (HA) have yielded insights for antiviral development. Here, the authors employ saturated mutagenesis of the paratope region of a bnAb combined with yeast display screening using H1 and H3 HAs, and find that a tradeoff exists bet...

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Autores principales: Nicholas C. Wu, Geramie Grande, Hannah L. Turner, Andrew B. Ward, Jia Xie, Richard A. Lerner, Ian A. Wilson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/288a464640f848a88e3527b72a95a760
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