WRN regulates pathway choice between classical and alternative non-homologous end joining

Werner Syndrome is an accelerated aging disorder marked by genome instability, large deletions and telomere fusions, hallmarks of aberrant DNA repair. Here the authors report a role for the WRN helicase in regulating the choice between classical and alternative non-homologous end-joning.

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Autores principales:	Raghavendra A. Shamanna, Huiming Lu, Jessica K. de Freitas, Jane Tian, Deborah L. Croteau, Vilhelm A. Bohr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/288f880dc0b0490f9a023dfa7e90c874
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spelling	oai:doaj.org-article:288f880dc0b0490f9a023dfa7e90c8742021-12-02T14:39:11ZWRN regulates pathway choice between classical and alternative non-homologous end joining10.1038/ncomms137852041-1723https://doaj.org/article/288f880dc0b0490f9a023dfa7e90c8742016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13785https://doaj.org/toc/2041-1723Werner Syndrome is an accelerated aging disorder marked by genome instability, large deletions and telomere fusions, hallmarks of aberrant DNA repair. Here the authors report a role for the WRN helicase in regulating the choice between classical and alternative non-homologous end-joning.Raghavendra A. ShamannaHuiming LuJessica K. de FreitasJane TianDeborah L. CroteauVilhelm A. BohrNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raghavendra A. Shamanna Huiming Lu Jessica K. de Freitas Jane Tian Deborah L. Croteau Vilhelm A. Bohr WRN regulates pathway choice between classical and alternative non-homologous end joining
description	Werner Syndrome is an accelerated aging disorder marked by genome instability, large deletions and telomere fusions, hallmarks of aberrant DNA repair. Here the authors report a role for the WRN helicase in regulating the choice between classical and alternative non-homologous end-joning.
format	article
author	Raghavendra A. Shamanna Huiming Lu Jessica K. de Freitas Jane Tian Deborah L. Croteau Vilhelm A. Bohr
author_facet	Raghavendra A. Shamanna Huiming Lu Jessica K. de Freitas Jane Tian Deborah L. Croteau Vilhelm A. Bohr
author_sort	Raghavendra A. Shamanna
title	WRN regulates pathway choice between classical and alternative non-homologous end joining
title_short	WRN regulates pathway choice between classical and alternative non-homologous end joining
title_full	WRN regulates pathway choice between classical and alternative non-homologous end joining
title_fullStr	WRN regulates pathway choice between classical and alternative non-homologous end joining
title_full_unstemmed	WRN regulates pathway choice between classical and alternative non-homologous end joining
title_sort	wrn regulates pathway choice between classical and alternative non-homologous end joining
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/288f880dc0b0490f9a023dfa7e90c874
work_keys_str_mv	AT raghavendraashamanna wrnregulatespathwaychoicebetweenclassicalandalternativenonhomologousendjoining AT huiminglu wrnregulatespathwaychoicebetweenclassicalandalternativenonhomologousendjoining AT jessicakdefreitas wrnregulatespathwaychoicebetweenclassicalandalternativenonhomologousendjoining AT janetian wrnregulatespathwaychoicebetweenclassicalandalternativenonhomologousendjoining AT deborahlcroteau wrnregulatespathwaychoicebetweenclassicalandalternativenonhomologousendjoining AT vilhelmabohr wrnregulatespathwaychoicebetweenclassicalandalternativenonhomologousendjoining
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WRN regulates pathway choice between classical and alternative non-homologous end joining

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