The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the glycosphingolipid galactocerebroside degradation mecha...

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Autores principales:	Chris H. Hill, Georgia M. Cook, Samantha J. Spratley, Stuart Fawke, Stephen C. Graham, Janet E. Deane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2892fdb00d5d43eb9babf8bf3fb7a3dc
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spelling	oai:doaj.org-article:2892fdb00d5d43eb9babf8bf3fb7a3dc2021-12-02T14:41:28ZThe mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure10.1038/s41467-017-02361-y2041-1723https://doaj.org/article/2892fdb00d5d43eb9babf8bf3fb7a3dc2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02361-yhttps://doaj.org/toc/2041-1723Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the glycosphingolipid galactocerebroside degradation mechanism.Chris H. HillGeorgia M. CookSamantha J. SpratleyStuart FawkeStephen C. GrahamJanet E. DeaneNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chris H. Hill Georgia M. Cook Samantha J. Spratley Stuart Fawke Stephen C. Graham Janet E. Deane The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
description	Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the glycosphingolipid galactocerebroside degradation mechanism.
format	article
author	Chris H. Hill Georgia M. Cook Samantha J. Spratley Stuart Fawke Stephen C. Graham Janet E. Deane
author_facet	Chris H. Hill Georgia M. Cook Samantha J. Spratley Stuart Fawke Stephen C. Graham Janet E. Deane
author_sort	Chris H. Hill
title	The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
title_short	The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
title_full	The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
title_fullStr	The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
title_full_unstemmed	The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure
title_sort	mechanism of glycosphingolipid degradation revealed by a galc-sapa complex structure
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2892fdb00d5d43eb9babf8bf3fb7a3dc
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The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

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