Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)

We aimed to compare the outcomes of patients under veno-venous extracorporeal membrane oxygenation (V-V ECMO) for COVID-19-Acute Respiratory Distress Syndrome (CARDS) between the first and the second wave. From 1 March 2020 to 30 November 2020, fifty patients requiring a V-V ECMO support for CARDS w...

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Autores principales:	Nicolas Dognon, Alexandre Gaudet, Erika Parmentier-Decrucq, Sylvain Normandin, André Vincentelli, Mouhamed Moussa, Julien Poissy, Thibault Duburcq, Lille Intensive Care COVID-19 Group
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	extracorporeal membrane oxygenation COVID 2019 acute respiratory distress syndrome outbreak waves respiratory drive ventilator-associated pneumonia Medicine R
Acceso en línea:	https://doaj.org/article/28964268c2854417b3ab3d2b8ea683bc
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spelling	oai:doaj.org-article:28964268c2854417b3ab3d2b8ea683bc2021-11-11T17:30:29ZExtracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)10.3390/jcm102148392077-0383https://doaj.org/article/28964268c2854417b3ab3d2b8ea683bc2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4839https://doaj.org/toc/2077-0383We aimed to compare the outcomes of patients under veno-venous extracorporeal membrane oxygenation (V-V ECMO) for COVID-19-Acute Respiratory Distress Syndrome (CARDS) between the first and the second wave. From 1 March 2020 to 30 November 2020, fifty patients requiring a V-V ECMO support for CARDS were included. Patient demographics, pre-ECMO, and day one, three, and seven on-ECMO data and outcomes were collected. The 90-day mortality was 11% higher during the second wave (18/26 (69%)) compared to the first wave (14/24 (58%) (<i>p</i> = 0.423). During the second wave, all of the patients were given steroids compared to 16.7% during the first wave (<i>p</i> < 0.001). The second wave’s patients had been on non-invasive ventilation support for a longer period than in the first wave, with the median time from ICU admission to ECMO implantation being significantly higher (14 (11–20) vs. 7.7 (5–12) days; <i>p</i> < 0.001). Mechanical properties of the lung were worsened in the second wave’s CARDS patients before ECMO implantation (median static compliance 20 (16–26) vs. 29 (25–37) mL/cmH2O; <i>p</i> < 0.001) and during ECMO days one, three, and seven. More bacterial co-infections before implantation and under ECMO were documented in the second wave group. Despite a better evidence-driven critical care management, we depicted fewer encouraging outcomes during the second wave.Nicolas DognonAlexandre GaudetErika Parmentier-DecrucqSylvain NormandinAndré VincentelliMouhamed MoussaJulien PoissyThibault DuburcqLille Intensive Care COVID-19 GroupMDPI AGarticleextracorporeal membrane oxygenationCOVID 2019acute respiratory distress syndromeoutbreak wavesrespiratory driveventilator-associated pneumoniaMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4839, p 4839 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracorporeal membrane oxygenation COVID 2019 acute respiratory distress syndrome outbreak waves respiratory drive ventilator-associated pneumonia Medicine R
spellingShingle	extracorporeal membrane oxygenation COVID 2019 acute respiratory distress syndrome outbreak waves respiratory drive ventilator-associated pneumonia Medicine R Nicolas Dognon Alexandre Gaudet Erika Parmentier-Decrucq Sylvain Normandin André Vincentelli Mouhamed Moussa Julien Poissy Thibault Duburcq Lille Intensive Care COVID-19 Group Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
description	We aimed to compare the outcomes of patients under veno-venous extracorporeal membrane oxygenation (V-V ECMO) for COVID-19-Acute Respiratory Distress Syndrome (CARDS) between the first and the second wave. From 1 March 2020 to 30 November 2020, fifty patients requiring a V-V ECMO support for CARDS were included. Patient demographics, pre-ECMO, and day one, three, and seven on-ECMO data and outcomes were collected. The 90-day mortality was 11% higher during the second wave (18/26 (69%)) compared to the first wave (14/24 (58%) (<i>p</i> = 0.423). During the second wave, all of the patients were given steroids compared to 16.7% during the first wave (<i>p</i> < 0.001). The second wave’s patients had been on non-invasive ventilation support for a longer period than in the first wave, with the median time from ICU admission to ECMO implantation being significantly higher (14 (11–20) vs. 7.7 (5–12) days; <i>p</i> < 0.001). Mechanical properties of the lung were worsened in the second wave’s CARDS patients before ECMO implantation (median static compliance 20 (16–26) vs. 29 (25–37) mL/cmH2O; <i>p</i> < 0.001) and during ECMO days one, three, and seven. More bacterial co-infections before implantation and under ECMO were documented in the second wave group. Despite a better evidence-driven critical care management, we depicted fewer encouraging outcomes during the second wave.
format	article
author	Nicolas Dognon Alexandre Gaudet Erika Parmentier-Decrucq Sylvain Normandin André Vincentelli Mouhamed Moussa Julien Poissy Thibault Duburcq Lille Intensive Care COVID-19 Group
author_facet	Nicolas Dognon Alexandre Gaudet Erika Parmentier-Decrucq Sylvain Normandin André Vincentelli Mouhamed Moussa Julien Poissy Thibault Duburcq Lille Intensive Care COVID-19 Group
author_sort	Nicolas Dognon
title	Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
title_short	Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
title_full	Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
title_fullStr	Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
title_full_unstemmed	Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)
title_sort	extracorporeal membrane oxygenation for covid 2019-acute respiratory distress syndrome: comparison between first and second waves (stage 2)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/28964268c2854417b3ab3d2b8ea683bc
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Extracorporeal Membrane Oxygenation for COVID 2019-Acute Respiratory Distress Syndrome: Comparison between First and Second Waves (Stage 2)

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