Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds

Annapoorna Mohandas,* Sudheesh Kumar PT,* Biswas Raja, Vinoth-Kumar Lakshmanan, Rangasamy Jayakumar Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India *These authors contributed equall...

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Autores principales:	Mohandas A, PT SK, Raja B, Lakshmanan VK, Jayakumar R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/289668ebe09c471c93731ad4e4089e13
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spelling	oai:doaj.org-article:289668ebe09c471c93731ad4e4089e132021-12-02T01:10:24ZExploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds1178-2013https://doaj.org/article/289668ebe09c471c93731ad4e4089e132015-10-01T00:00:00Zhttps://www.dovepress.com/exploration-of-alginate-hydrogelnano-zinc-oxide-composite-bandages-for-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Annapoorna Mohandas,* Sudheesh Kumar PT,* Biswas Raja, Vinoth-Kumar Lakshmanan, Rangasamy Jayakumar Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India *These authors contributed equally to this work Abstract: Alginate hydrogel/zinc oxide nanoparticles (nZnO) composite bandage was developed by freeze-dry method from the mixture of nZnO and alginate hydrogel. The developed composite bandage was porous with porosity at a range of 60%–70%. The swelling ratios of the bandages decreased with increasing concentrations of nZnO. The composite bandages with nZnO incorporation showed controlled degradation profile and faster blood clotting ability when compared to the KALTOSTAT® and control bandages without nZnO. The prepared composite bandages exhibited excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and methicillin resistant S. aureus (MRSA). Cytocompatibility evaluation of the prepared composite bandages done on human dermal fibroblast cells by Alamar assay and infiltration studies proved that the bandages have a non-toxic nature at lower concentrations of nZnO whereas slight reduction in viability was seen with increasing nZnO concentrations. The qualitative analysis of ex-vivo re-epithelialization on porcine skin revealed keratinocyte infiltration toward wound area for nZnO alginate bandages. Keywords: alginate, hydrogel, ZnO nanoparticle, hemostatic, antimicrobial activity, wound healingMohandas APT SKRaja BLakshmanan VKJayakumar RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Supplement 1 Challenges in biomaterials research, Pp 53-66 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mohandas A PT SK Raja B Lakshmanan VK Jayakumar R Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
description	Annapoorna Mohandas,* Sudheesh Kumar PT,* Biswas Raja, Vinoth-Kumar Lakshmanan, Rangasamy Jayakumar Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi, India *These authors contributed equally to this work Abstract: Alginate hydrogel/zinc oxide nanoparticles (nZnO) composite bandage was developed by freeze-dry method from the mixture of nZnO and alginate hydrogel. The developed composite bandage was porous with porosity at a range of 60%–70%. The swelling ratios of the bandages decreased with increasing concentrations of nZnO. The composite bandages with nZnO incorporation showed controlled degradation profile and faster blood clotting ability when compared to the KALTOSTAT® and control bandages without nZnO. The prepared composite bandages exhibited excellent antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and methicillin resistant S. aureus (MRSA). Cytocompatibility evaluation of the prepared composite bandages done on human dermal fibroblast cells by Alamar assay and infiltration studies proved that the bandages have a non-toxic nature at lower concentrations of nZnO whereas slight reduction in viability was seen with increasing nZnO concentrations. The qualitative analysis of ex-vivo re-epithelialization on porcine skin revealed keratinocyte infiltration toward wound area for nZnO alginate bandages. Keywords: alginate, hydrogel, ZnO nanoparticle, hemostatic, antimicrobial activity, wound healing
format	article
author	Mohandas A PT SK Raja B Lakshmanan VK Jayakumar R
author_facet	Mohandas A PT SK Raja B Lakshmanan VK Jayakumar R
author_sort	Mohandas A
title	Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
title_short	Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
title_full	Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
title_fullStr	Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
title_full_unstemmed	Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
title_sort	exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/289668ebe09c471c93731ad4e4089e13
work_keys_str_mv	AT mohandasa explorationofalginatehydrogelnanozincoxidecompositebandagesforinfectedwounds AT ptsk explorationofalginatehydrogelnanozincoxidecompositebandagesforinfectedwounds AT rajab explorationofalginatehydrogelnanozincoxidecompositebandagesforinfectedwounds AT lakshmananvk explorationofalginatehydrogelnanozincoxidecompositebandagesforinfectedwounds AT jayakumarr explorationofalginatehydrogelnanozincoxidecompositebandagesforinfectedwounds
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Exploration of alginate hydrogel/nano zinc oxide composite bandages for infected wounds

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