High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure

Advances in meticulous dural closure technique remain a great challenge for watertight dural closure in the aged society, because the cerebrospinal fluid (CSF) leakage after spinal surgery is often accompanied with the disgusting wound infection, meningitis and pseudomeningocele. Here, a tetra-poly...

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Autores principales:	Tengjiao Zhu, Hufei Wang, Zehao Jing, Daoyang Fan, Zhongjun Liu, Xing Wang, Yun Tian
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	CSF leakage Dural repair Watertight closure Sutureless Tetra-PEG hydrogel Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/289a67bb22ae4e6b816c4cbbfe528fbb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:289a67bb22ae4e6b816c4cbbfe528fbb2021-11-04T04:35:44ZHigh efficacy of tetra-PEG hydrogel sealants for sutureless dural closure2452-199X10.1016/j.bioactmat.2021.06.022https://doaj.org/article/289a67bb22ae4e6b816c4cbbfe528fbb2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X2100308Xhttps://doaj.org/toc/2452-199XAdvances in meticulous dural closure technique remain a great challenge for watertight dural closure in the aged society, because the cerebrospinal fluid (CSF) leakage after spinal surgery is often accompanied with the disgusting wound infection, meningitis and pseudomeningocele. Here, a tetra-poly (ethylene glycol) (PEG)-based hydrogel sealant is developed with collective advantages of facile operation, high safety, quick set time, easy injectability, favorable mechanical strength and powerful tissue adhesion for effective sutureless dural closure during the surgery procedure. Impressively, this tetra-PEG sealant can instantaneously adhere to the irregular tissue surfaces even in a liquid environment, and effectively prevent or block off the intraoperative CSF leakage for sutureless dural closure and dura regeneration. Together, this sutureless tetra-PEG adhesive can be utilized as a very promising alternative for high-efficient watertight dural closure of the clinical patients who incidentally or deliberately undergo the durotomy during the spinal surgery.Tengjiao ZhuHufei WangZehao JingDaoyang FanZhongjun LiuXing WangYun TianKeAi Communications Co., Ltd.articleCSF leakageDural repairWatertight closureSuturelessTetra-PEG hydrogelMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 12-19 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	CSF leakage Dural repair Watertight closure Sutureless Tetra-PEG hydrogel Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	CSF leakage Dural repair Watertight closure Sutureless Tetra-PEG hydrogel Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Tengjiao Zhu Hufei Wang Zehao Jing Daoyang Fan Zhongjun Liu Xing Wang Yun Tian High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
description	Advances in meticulous dural closure technique remain a great challenge for watertight dural closure in the aged society, because the cerebrospinal fluid (CSF) leakage after spinal surgery is often accompanied with the disgusting wound infection, meningitis and pseudomeningocele. Here, a tetra-poly (ethylene glycol) (PEG)-based hydrogel sealant is developed with collective advantages of facile operation, high safety, quick set time, easy injectability, favorable mechanical strength and powerful tissue adhesion for effective sutureless dural closure during the surgery procedure. Impressively, this tetra-PEG sealant can instantaneously adhere to the irregular tissue surfaces even in a liquid environment, and effectively prevent or block off the intraoperative CSF leakage for sutureless dural closure and dura regeneration. Together, this sutureless tetra-PEG adhesive can be utilized as a very promising alternative for high-efficient watertight dural closure of the clinical patients who incidentally or deliberately undergo the durotomy during the spinal surgery.
format	article
author	Tengjiao Zhu Hufei Wang Zehao Jing Daoyang Fan Zhongjun Liu Xing Wang Yun Tian
author_facet	Tengjiao Zhu Hufei Wang Zehao Jing Daoyang Fan Zhongjun Liu Xing Wang Yun Tian
author_sort	Tengjiao Zhu
title	High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
title_short	High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
title_full	High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
title_fullStr	High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
title_full_unstemmed	High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure
title_sort	high efficacy of tetra-peg hydrogel sealants for sutureless dural closure
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/289a67bb22ae4e6b816c4cbbfe528fbb
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High efficacy of tetra-PEG hydrogel sealants for sutureless dural closure

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