The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.
Colorectal cancer (CRC) is associated with lifestyle factors that affect insulin/IGF signaling, of which the insulin receptor substrate 1 (IRS1) is a key transducer. We investigated expression, localization and pathologic correlations of IRS1 in cancer-uninvolved colonic epithelium, primary CRCs wit...
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Autores principales: | Diana L Esposito, Federica Aru, Rossano Lattanzio, Annalisa Morgano, Michela Abbondanza, Reza Malekzadeh, Faraz Bishehsari, Rosa Valanzano, Antonio Russo, Mauro Piantelli, Antonio Moschetta, Lavinia Vittoria Lotti, Renato Mariani-Costantini |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/289c7a54eecd4ce7808739bc6bb5b28b |
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