Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study

Abstract Background Nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GSD) often coexist in the general population owing to shared risk factors. This study explored the relationship between NAFLD and GSD in patients with type 2 diabetes. Methods We conducted a retrospective cross-secti...

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Autores principales:	Ye Lu, Lili Hu, Jing Song, Jing Wan, Haibing Chen, Jun Yin
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Type 2 diabetes mellitus Gallstone disease Cholecystectomy Nonalcoholic fatty liver disease Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/289ce7ea153b4d0caef936745b69dd26
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spelling	oai:doaj.org-article:289ce7ea153b4d0caef936745b69dd262021-11-21T12:02:18ZGallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study10.1186/s12902-021-00899-z1472-6823https://doaj.org/article/289ce7ea153b4d0caef936745b69dd262021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00899-zhttps://doaj.org/toc/1472-6823Abstract Background Nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GSD) often coexist in the general population owing to shared risk factors. This study explored the relationship between NAFLD and GSD in patients with type 2 diabetes. Methods We conducted a retrospective cross-sectional analysis of 4325 patients with type 2 diabetes. GSD and NAFLD were confirmed using ultrasonography. GSD was defined as either asymptomatic gallstones or previous cholecystectomy, and each was analyzed separately. Result There was no significant difference in the prevalence of GSD between patients with and without NAFLD (23.8% vs. 21.2%, P = 0.15). After case–control matching (1:1) of baseline data such as age, sex, duration of diabetes, and HbA1c between patients with and without NAFLD, there was still no significant difference in the prevalence of GSD (25.5% vs. 23.6%, P = 0.15). The prevalence of NAFLD in patients with asymptomatic gallstones was lower than that of patients without GSD (38.6% vs. 47.3%, P < 0.001), whereas the prevalence in those who had undergone cholecystectomy was much higher (61.2% vs. 47.3%, P < 0.001). The ratio of cholecystectomy to asymptomatic gallstone in patients with or without NAFLD was 1.97 and 0.79, respectively. The rate of cholecystectomy was higher in the patients with NAFLD than in those without NAFLD (15.8% vs. 9.3%, P < 0.001), consistent with the result after case–control matching (17.3% vs. 11.2%, P < 0.001). Multivariate logistic regression analysis, after adjusting for numerous potential confounding factors, revealed that GSD (OR = 1.241, 95%CI: 1.036–1.488, P = 0.002) and cholecystectomy (OR = 1.946, 95%CI: 1.546–2.445, P < 0.001) were both strongly associated with NAFLD. However, asymptomatic gallstone (OR = 0.663, 95%CI: 0.513–0.856, P = 0.002) seemed to be negatively correlated with NAFLD. Conclusions The prevalence of GSD was similar in patients with type 2 diabetes with and without NAFLD. The higher proportion of cholecystectomy and lower proportion of asymptomatic gallstones in patients with NAFLD suggests that NAFLD may increase the risk of complications of GSD.Ye LuLili HuJing SongJing WanHaibing ChenJun YinBMCarticleType 2 diabetes mellitusGallstone diseaseCholecystectomyNonalcoholic fatty liver diseaseDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes mellitus Gallstone disease Cholecystectomy Nonalcoholic fatty liver disease Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Type 2 diabetes mellitus Gallstone disease Cholecystectomy Nonalcoholic fatty liver disease Diseases of the endocrine glands. Clinical endocrinology RC648-665 Ye Lu Lili Hu Jing Song Jing Wan Haibing Chen Jun Yin Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
description	Abstract Background Nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GSD) often coexist in the general population owing to shared risk factors. This study explored the relationship between NAFLD and GSD in patients with type 2 diabetes. Methods We conducted a retrospective cross-sectional analysis of 4325 patients with type 2 diabetes. GSD and NAFLD were confirmed using ultrasonography. GSD was defined as either asymptomatic gallstones or previous cholecystectomy, and each was analyzed separately. Result There was no significant difference in the prevalence of GSD between patients with and without NAFLD (23.8% vs. 21.2%, P = 0.15). After case–control matching (1:1) of baseline data such as age, sex, duration of diabetes, and HbA1c between patients with and without NAFLD, there was still no significant difference in the prevalence of GSD (25.5% vs. 23.6%, P = 0.15). The prevalence of NAFLD in patients with asymptomatic gallstones was lower than that of patients without GSD (38.6% vs. 47.3%, P < 0.001), whereas the prevalence in those who had undergone cholecystectomy was much higher (61.2% vs. 47.3%, P < 0.001). The ratio of cholecystectomy to asymptomatic gallstone in patients with or without NAFLD was 1.97 and 0.79, respectively. The rate of cholecystectomy was higher in the patients with NAFLD than in those without NAFLD (15.8% vs. 9.3%, P < 0.001), consistent with the result after case–control matching (17.3% vs. 11.2%, P < 0.001). Multivariate logistic regression analysis, after adjusting for numerous potential confounding factors, revealed that GSD (OR = 1.241, 95%CI: 1.036–1.488, P = 0.002) and cholecystectomy (OR = 1.946, 95%CI: 1.546–2.445, P < 0.001) were both strongly associated with NAFLD. However, asymptomatic gallstone (OR = 0.663, 95%CI: 0.513–0.856, P = 0.002) seemed to be negatively correlated with NAFLD. Conclusions The prevalence of GSD was similar in patients with type 2 diabetes with and without NAFLD. The higher proportion of cholecystectomy and lower proportion of asymptomatic gallstones in patients with NAFLD suggests that NAFLD may increase the risk of complications of GSD.
format	article
author	Ye Lu Lili Hu Jing Song Jing Wan Haibing Chen Jun Yin
author_facet	Ye Lu Lili Hu Jing Song Jing Wan Haibing Chen Jun Yin
author_sort	Ye Lu
title	Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
title_short	Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
title_full	Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
title_fullStr	Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
title_full_unstemmed	Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
title_sort	gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/289ce7ea153b4d0caef936745b69dd26
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Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study

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