Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

Retinoblastoma (RB) is one of the most common intraocular malignancies in children, which causes vision loss and even threatens life. Eriodictyol is a natural flavonoid with strong anticancer activity. Some studies have shown that eriodictyol exerts anticancer effects in glioma, colon cancer, and lu...

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Autores principales:	Shu Wen, Meng Hu, Yan Xiong
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/289d799ac1414beeb009fd3e4ba6793b
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spelling	oai:doaj.org-article:289d799ac1414beeb009fd3e4ba6793b2021-11-22T01:11:02ZEffect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway2040-230910.1155/2021/6091585https://doaj.org/article/289d799ac1414beeb009fd3e4ba6793b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6091585https://doaj.org/toc/2040-2309Retinoblastoma (RB) is one of the most common intraocular malignancies in children, which causes vision loss and even threatens life. Eriodictyol is a natural flavonoid with strong anticancer activity. Some studies have shown that eriodictyol exerts anticancer effects in glioma, colon cancer, and lung cancer; however, no studies have reported the anticancer effects of eriodictyol on RB. Therefore, the aim of this study was to investigate the anticancer activity of eriodictyol against the RB Y79 cell line and its potential mechanism of action. Interestingly, we found that eriodictyol inhibited the proliferation, migration, and invasion of Y79 cells in a dose-dependent manner and decreased the expression of MMP-2 and MMP-9 proteins in the cells. In addition, eriodictyol-induced apoptosis in Y79 cells was assessed by flow cytometry and immunoblotting. Here, our study revealed that eriodictyol dose dependently inhibited the activation of the PI3K/Akt signaling pathway. Notably, the effect of eriodictyol on RB apoptosis was reversed by a PI3K agonist 740 Y-P. In conclusion, our study shows that eriodictyol effectively inhibits proliferation, migration, and invasion and induces apoptosis in RB cell lines, which may be the result of blocking the PI3K/Akt signaling pathway. Thus, eriodictyol may provide a new theoretical basis for exploring targeted antitumor natural therapies.Shu WenMeng HuYan XiongHindawi LimitedarticleMedicine (General)R5-920Medical technologyR855-855.5ENJournal of Healthcare Engineering, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Medical technology R855-855.5
spellingShingle	Medicine (General) R5-920 Medical technology R855-855.5 Shu Wen Meng Hu Yan Xiong Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
description	Retinoblastoma (RB) is one of the most common intraocular malignancies in children, which causes vision loss and even threatens life. Eriodictyol is a natural flavonoid with strong anticancer activity. Some studies have shown that eriodictyol exerts anticancer effects in glioma, colon cancer, and lung cancer; however, no studies have reported the anticancer effects of eriodictyol on RB. Therefore, the aim of this study was to investigate the anticancer activity of eriodictyol against the RB Y79 cell line and its potential mechanism of action. Interestingly, we found that eriodictyol inhibited the proliferation, migration, and invasion of Y79 cells in a dose-dependent manner and decreased the expression of MMP-2 and MMP-9 proteins in the cells. In addition, eriodictyol-induced apoptosis in Y79 cells was assessed by flow cytometry and immunoblotting. Here, our study revealed that eriodictyol dose dependently inhibited the activation of the PI3K/Akt signaling pathway. Notably, the effect of eriodictyol on RB apoptosis was reversed by a PI3K agonist 740 Y-P. In conclusion, our study shows that eriodictyol effectively inhibits proliferation, migration, and invasion and induces apoptosis in RB cell lines, which may be the result of blocking the PI3K/Akt signaling pathway. Thus, eriodictyol may provide a new theoretical basis for exploring targeted antitumor natural therapies.
format	article
author	Shu Wen Meng Hu Yan Xiong
author_facet	Shu Wen Meng Hu Yan Xiong
author_sort	Shu Wen
title	Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
title_short	Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
title_full	Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
title_fullStr	Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
title_full_unstemmed	Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway
title_sort	effect of eriodictyol on retinoblastoma via the pi3k/akt pathway
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/289d799ac1414beeb009fd3e4ba6793b
work_keys_str_mv	AT shuwen effectoferiodictyolonretinoblastomaviathepi3kaktpathway AT menghu effectoferiodictyolonretinoblastomaviathepi3kaktpathway AT yanxiong effectoferiodictyolonretinoblastomaviathepi3kaktpathway
_version_	1718418328944377856

Effect of Eriodictyol on Retinoblastoma via the PI3K/Akt Pathway

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