Two Faces of Macrophages: Training and Tolerance

Macrophages are present in almost all body tissues. They detect and quickly respond to “environmental signals” in the tissue. Macrophages have been associated with numerous beneficial roles, such as host defense, wound healing, and tissue regeneration; however, they have also been linked to the deve...

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Autores principales:	Kiran Zubair, Chaelin You, Geunho Kwon, Kyuho Kang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	macrophages innate immune memory trained immunity tolerance epigenetics inflammatory diseases Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/289d8b3662ac4332b1a2f0c229d27f04
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id	oai:doaj.org-article:289d8b3662ac4332b1a2f0c229d27f04
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spelling	oai:doaj.org-article:289d8b3662ac4332b1a2f0c229d27f042021-11-25T16:49:27ZTwo Faces of Macrophages: Training and Tolerance10.3390/biomedicines91115962227-9059https://doaj.org/article/289d8b3662ac4332b1a2f0c229d27f042021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1596https://doaj.org/toc/2227-9059Macrophages are present in almost all body tissues. They detect and quickly respond to “environmental signals” in the tissue. Macrophages have been associated with numerous beneficial roles, such as host defense, wound healing, and tissue regeneration; however, they have also been linked to the development of diverse illnesses, particularly cancers and autoimmune disorders. Complex signaling, epigenetic, and metabolic pathways drive macrophage training and tolerance. The induced intracellular program differs depending on the type of initial stimuli and the tissue microenvironment. Due to the essential roles of macrophages in homeostatic and their association with the pathogenesis of inflammatory diseases, recent studies have investigated the molecular mechanisms of macrophage training and tolerance. This review discusses the role of factors involved in macrophage training and tolerance, along with the current studies in human diseases.Kiran ZubairChaelin YouGeunho KwonKyuho KangMDPI AGarticlemacrophagesinnate immune memorytrained immunitytoleranceepigeneticsinflammatory diseasesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1596, p 1596 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrophages innate immune memory trained immunity tolerance epigenetics inflammatory diseases Biology (General) QH301-705.5
spellingShingle	macrophages innate immune memory trained immunity tolerance epigenetics inflammatory diseases Biology (General) QH301-705.5 Kiran Zubair Chaelin You Geunho Kwon Kyuho Kang Two Faces of Macrophages: Training and Tolerance
description	Macrophages are present in almost all body tissues. They detect and quickly respond to “environmental signals” in the tissue. Macrophages have been associated with numerous beneficial roles, such as host defense, wound healing, and tissue regeneration; however, they have also been linked to the development of diverse illnesses, particularly cancers and autoimmune disorders. Complex signaling, epigenetic, and metabolic pathways drive macrophage training and tolerance. The induced intracellular program differs depending on the type of initial stimuli and the tissue microenvironment. Due to the essential roles of macrophages in homeostatic and their association with the pathogenesis of inflammatory diseases, recent studies have investigated the molecular mechanisms of macrophage training and tolerance. This review discusses the role of factors involved in macrophage training and tolerance, along with the current studies in human diseases.
format	article
author	Kiran Zubair Chaelin You Geunho Kwon Kyuho Kang
author_facet	Kiran Zubair Chaelin You Geunho Kwon Kyuho Kang
author_sort	Kiran Zubair
title	Two Faces of Macrophages: Training and Tolerance
title_short	Two Faces of Macrophages: Training and Tolerance
title_full	Two Faces of Macrophages: Training and Tolerance
title_fullStr	Two Faces of Macrophages: Training and Tolerance
title_full_unstemmed	Two Faces of Macrophages: Training and Tolerance
title_sort	two faces of macrophages: training and tolerance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/289d8b3662ac4332b1a2f0c229d27f04
work_keys_str_mv	AT kiranzubair twofacesofmacrophagestrainingandtolerance AT chaelinyou twofacesofmacrophagestrainingandtolerance AT geunhokwon twofacesofmacrophagestrainingandtolerance AT kyuhokang twofacesofmacrophagestrainingandtolerance
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Two Faces of Macrophages: Training and Tolerance

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