Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

RNA chaperones, such as the hepatitic C virus (HCV) core protein, are proteins that aid in the folding of nucleic acids. Here authors use single‐molecule spectroscopy and simulation to show that the HCV core protein acts as a flexible macromolecular counterion which facilitates nucleic acid folding....

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Autores principales:	Erik D. Holmstrom, Zhaowei Liu, Daniel Nettels, Robert B. Best, Benjamin Schuler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/289f20cc4cd4465ab566f9409c9f7499
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spelling	oai:doaj.org-article:289f20cc4cd4465ab566f9409c9f74992021-12-02T15:35:58ZDisordered RNA chaperones can enhance nucleic acid folding via local charge screening10.1038/s41467-019-10356-02041-1723https://doaj.org/article/289f20cc4cd4465ab566f9409c9f74992019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10356-0https://doaj.org/toc/2041-1723RNA chaperones, such as the hepatitic C virus (HCV) core protein, are proteins that aid in the folding of nucleic acids. Here authors use single‐molecule spectroscopy and simulation to show that the HCV core protein acts as a flexible macromolecular counterion which facilitates nucleic acid folding.Erik D. HolmstromZhaowei LiuDaniel NettelsRobert B. BestBenjamin SchulerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik D. Holmstrom Zhaowei Liu Daniel Nettels Robert B. Best Benjamin Schuler Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
description	RNA chaperones, such as the hepatitic C virus (HCV) core protein, are proteins that aid in the folding of nucleic acids. Here authors use single‐molecule spectroscopy and simulation to show that the HCV core protein acts as a flexible macromolecular counterion which facilitates nucleic acid folding.
format	article
author	Erik D. Holmstrom Zhaowei Liu Daniel Nettels Robert B. Best Benjamin Schuler
author_facet	Erik D. Holmstrom Zhaowei Liu Daniel Nettels Robert B. Best Benjamin Schuler
author_sort	Erik D. Holmstrom
title	Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
title_short	Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
title_full	Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
title_fullStr	Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
title_full_unstemmed	Disordered RNA chaperones can enhance nucleic acid folding via local charge screening
title_sort	disordered rna chaperones can enhance nucleic acid folding via local charge screening
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/289f20cc4cd4465ab566f9409c9f7499
work_keys_str_mv	AT erikdholmstrom disorderedrnachaperonescanenhancenucleicacidfoldingvialocalchargescreening AT zhaoweiliu disorderedrnachaperonescanenhancenucleicacidfoldingvialocalchargescreening AT danielnettels disorderedrnachaperonescanenhancenucleicacidfoldingvialocalchargescreening AT robertbbest disorderedrnachaperonescanenhancenucleicacidfoldingvialocalchargescreening AT benjaminschuler disorderedrnachaperonescanenhancenucleicacidfoldingvialocalchargescreening
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Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

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