Disordered RNA chaperones can enhance nucleic acid folding via local charge screening

RNA chaperones, such as the hepatitic C virus (HCV) core protein, are proteins that aid in the folding of nucleic acids. Here authors use single‐molecule spectroscopy and simulation to show that the HCV core protein acts as a flexible macromolecular counterion which facilitates nucleic acid folding....

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Autores principales: Erik D. Holmstrom, Zhaowei Liu, Daniel Nettels, Robert B. Best, Benjamin Schuler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/289f20cc4cd4465ab566f9409c9f7499
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