Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.

<h4>Background</h4>Intermediate risk prostate cancer represents a largely heterogeneous group with diverse disease extent. We sought to establish rates of adverse pathological features important for radiation planning by analyzing surgical specimens from men with intermediate risk prosta...

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Autores principales:	Hong Zhang, Christopher Doucette, Hongmei Yang, Sanjukta Bandyopadhyay, Craig E Grossman, Edward M Messing, Yuhchyau Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28a042af608a4af8a9c3b03eeff01d18
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spelling	oai:doaj.org-article:28a042af608a4af8a9c3b03eeff01d182021-12-02T20:06:58ZRisk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.1932-620310.1371/journal.pone.0253936https://doaj.org/article/28a042af608a4af8a9c3b03eeff01d182021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253936https://doaj.org/toc/1932-6203<h4>Background</h4>Intermediate risk prostate cancer represents a largely heterogeneous group with diverse disease extent. We sought to establish rates of adverse pathological features important for radiation planning by analyzing surgical specimens from men with intermediate risk prostate cancer who underwent immediate radical prostatectomy, and to define clinical pathologic features that may predict adverse outcomes.<h4>Materials and methods</h4>A total of 1552 men diagnosed with intermediate risk prostate cancer who underwent immediate radical prostatectomy between 1/1/2005 and 12/31/2015 were reviewed. Inclusion criteria included available preoperative PSA level, pathology reports of transrectal ultrasound-guided prostate biopsy, and radical prostatectomy. Incidences of various pathological adverse features were evaluated. Patient characteristics and clinical disease features were analyzed for their predictive values.<h4>Results</h4>Fifty percent of men with high risk features (defined as PSA >10 but <20 or biopsy primary Gleason pattern of 4) had pathological upstage to T3 or higher disease. The incidence of upgrade to Gleason score of 8 or higher and the incidence of lymph node positive disease was low. Biopsy primary Gleason pattern of 4, and PSA greater than 10 but less than 20, affected adverse pathology in addition to age and percent positive biopsy cores. Older age and increased percentage of positive cores were significant risk factors of adverse pathology.<h4>Conclusion</h4>Our findings underscore the importance of comprehensive staging beyond PSA level, prostate biopsy, and CT/bone scan for men with intermediate risk prostate cancer proceeding with radiation in the era of highly conformal treatment.Hong ZhangChristopher DoucetteHongmei YangSanjukta BandyopadhyayCraig E GrossmanEdward M MessingYuhchyau ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253936 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hong Zhang Christopher Doucette Hongmei Yang Sanjukta Bandyopadhyay Craig E Grossman Edward M Messing Yuhchyau Chen Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
description	<h4>Background</h4>Intermediate risk prostate cancer represents a largely heterogeneous group with diverse disease extent. We sought to establish rates of adverse pathological features important for radiation planning by analyzing surgical specimens from men with intermediate risk prostate cancer who underwent immediate radical prostatectomy, and to define clinical pathologic features that may predict adverse outcomes.<h4>Materials and methods</h4>A total of 1552 men diagnosed with intermediate risk prostate cancer who underwent immediate radical prostatectomy between 1/1/2005 and 12/31/2015 were reviewed. Inclusion criteria included available preoperative PSA level, pathology reports of transrectal ultrasound-guided prostate biopsy, and radical prostatectomy. Incidences of various pathological adverse features were evaluated. Patient characteristics and clinical disease features were analyzed for their predictive values.<h4>Results</h4>Fifty percent of men with high risk features (defined as PSA >10 but <20 or biopsy primary Gleason pattern of 4) had pathological upstage to T3 or higher disease. The incidence of upgrade to Gleason score of 8 or higher and the incidence of lymph node positive disease was low. Biopsy primary Gleason pattern of 4, and PSA greater than 10 but less than 20, affected adverse pathology in addition to age and percent positive biopsy cores. Older age and increased percentage of positive cores were significant risk factors of adverse pathology.<h4>Conclusion</h4>Our findings underscore the importance of comprehensive staging beyond PSA level, prostate biopsy, and CT/bone scan for men with intermediate risk prostate cancer proceeding with radiation in the era of highly conformal treatment.
format	article
author	Hong Zhang Christopher Doucette Hongmei Yang Sanjukta Bandyopadhyay Craig E Grossman Edward M Messing Yuhchyau Chen
author_facet	Hong Zhang Christopher Doucette Hongmei Yang Sanjukta Bandyopadhyay Craig E Grossman Edward M Messing Yuhchyau Chen
author_sort	Hong Zhang
title	Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
title_short	Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
title_full	Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
title_fullStr	Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
title_full_unstemmed	Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.
title_sort	risk of adverse pathological features for intermediate risk prostate cancer: clinical implications for definitive radiation therapy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/28a042af608a4af8a9c3b03eeff01d18
work_keys_str_mv	AT hongzhang riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy AT christopherdoucette riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy AT hongmeiyang riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy AT sanjuktabandyopadhyay riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy AT craigegrossman riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy AT edwardmmessing riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy AT yuhchyauchen riskofadversepathologicalfeaturesforintermediateriskprostatecancerclinicalimplicationsfordefinitiveradiationtherapy
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Risk of adverse pathological features for intermediate risk prostate cancer: Clinical implications for definitive radiation therapy.

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