A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and media...

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Autores principales:	Xueyi Shen, David M. Howard, Mark J. Adams, W. David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28a072e158aa43dd8062b55e678c77e2
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spelling	oai:doaj.org-article:28a072e158aa43dd8062b55e678c77e22021-12-02T17:31:23ZA phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank10.1038/s41467-020-16022-02041-1723https://doaj.org/article/28a072e158aa43dd8062b55e678c77e22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16022-0https://doaj.org/toc/2041-1723Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.Xueyi ShenDavid M. HowardMark J. AdamsW. David HillToni-Kim ClarkeMajor Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumIan J. DearyHeather C. WhalleyAndrew M. McIntoshNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xueyi Shen David M. Howard Mark J. Adams W. David Hill Toni-Kim Clarke Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Ian J. Deary Heather C. Whalley Andrew M. McIntosh A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
description	Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.
format	article
author	Xueyi Shen David M. Howard Mark J. Adams W. David Hill Toni-Kim Clarke Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Ian J. Deary Heather C. Whalley Andrew M. McIntosh
author_facet	Xueyi Shen David M. Howard Mark J. Adams W. David Hill Toni-Kim Clarke Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Ian J. Deary Heather C. Whalley Andrew M. McIntosh
author_sort	Xueyi Shen
title	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_short	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_full	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_fullStr	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_full_unstemmed	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_sort	phenome-wide association and mendelian randomisation study of polygenic risk for depression in uk biobank
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/28a072e158aa43dd8062b55e678c77e2
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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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