Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence

Summary: Opiates produce a strong rewarding effect, but abstinence from opiate use emerges with severe negative emotions. Depression is one of the most frequent emotion disorders associated with opiate abstinence, which is thought to be a main cause for relapse. However, neurobiological bases of suc...

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Autores principales: Gui-Ying Zan, Yu-Jun Wang, Xue-Ping Li, Jun-Fan Fang, Song-Yu Yao, Jun-Ying Du, Qian Wang, Xiang Sun, Rui Liu, Xiao-Mei Shao, Jian-Dong Long, Jing-Rui Chai, Ying-Zhi Deng, Ye-Qing Chen, Qing-Lin Li, Jian-Qiao Fang, Zhi-Qiang Liu, Jing-Gen Liu
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/28a139f7693d43c18cec2da3add1381a
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