Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women

Background. Abnormal uterine bleeding (AUB) occurs in one-third of women of reproductive age and has a significant impact on women's lives, causing anemia, impaired social adaptation and professional activity. AUB-O (ovulatory dysfunction) is often caused by an excessive body mass (BM) and o...

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Autores principales:	Alina V. Solovyeva, Ildar F. Fatkullin, Artur R. Akhmetgaliev, Elena A. Vinokurova, Ekaterina Yu. Aleynikova, Olga A. Kuznetsova
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	abnormal uterine bleeding overweight obesity myoinositol d-chiroinositol dikirogen Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/28a19c1785464b589fcd742d6e75dbd7
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spelling	oai:doaj.org-article:28a19c1785464b589fcd742d6e75dbd72021-12-02T19:22:24ZComprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women2079-56962079-583110.26442/20795696.2021.5.201200https://doaj.org/article/28a19c1785464b589fcd742d6e75dbd72021-11-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/81479/pdfhttps://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Background. Abnormal uterine bleeding (AUB) occurs in one-third of women of reproductive age and has a significant impact on women's lives, causing anemia, impaired social adaptation and professional activity. AUB-O (ovulatory dysfunction) is often caused by an excessive body mass (BM) and obesity (especially visceral). The most effective option for restoring menstrual cycle (MC) in obese women is BM reduction. There is evidence that the combination of inositols myoinositol (MI) and D-chiroinositol (DCI) has a beneficial effect on BM loss, ovulation frequency and getting pregnant in women with polycystic ovary syndrome. Aim. To study the effect of MI and DHI in a 5:1 ratio in combination with diet and exercise on the regulation of MC in overweight and obese women. Materials and methods. The study has been conducted in clinics of Moscow, Kazan and Tyumen for 20202021. It is a descriptive study assessing an efficacy of lifestyle modification (diet and exercise) plus a nutritional support with a combination of 1000 mg MI and 200 mg DCI (ratio 5:1) for 24 months in 353 women of reproductive age with AMK-O and overweight or obesity. Efficacy criteria include: MC regularity, BM index (BMI), waist circumference (WC), levels of serum glucose, free testosterone, follicle-stimulating hormone, luteinizing hormone. Results. The study showed a significant shortening of MC to its physiological duration 3112.04 days (vs 4419.51 days at the 1st visit; p=0.001), a decrease in the rate of heavy bloody vaginal discharge by 2.57 times (p=0.001), an increase in the rate of moderate bloody vaginal discharge by 1,62 times (p=0.001), an increase in the proportion of patients with regular MC by 2.69 times (p=0.001). These changes were accompanied by a decrease in BM (-3 kg; p=0.001), a decrease in WC (-2.5 cm; p=0.001). Laboratory tests revealed a decrease in serum glucose (-1.3 mmol/L; p0.05), free testosterone (-0.4 pg/L; p0.05), luteinizing hormone (-0.8 mIU/ml; p0.05), and an increase in follicle-stimulating hormone (+0.1 mIU/ml; p0.05) levels. Conclusion. The results obtained (a decrease in BM, a decrease in BMI, WC, as well as MC restoration; p0.05) make it possible to recommend Dikirogen containing MI and DCI in a 5:1 ratio as a part of comprehensive therapy for overweight and obese women with AUB-O.Alina V. SolovyevaIldar F. FatkullinArtur R. AkhmetgalievElena A. VinokurovaEkaterina Yu. AleynikovaOlga A. KuznetsovaIP Berlin A.V. articleabnormal uterine bleedingoverweightobesitymyoinositold-chiroinositoldikirogenGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 5, Pp 402-406 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	abnormal uterine bleeding overweight obesity myoinositol d-chiroinositol dikirogen Gynecology and obstetrics RG1-991
spellingShingle	abnormal uterine bleeding overweight obesity myoinositol d-chiroinositol dikirogen Gynecology and obstetrics RG1-991 Alina V. Solovyeva Ildar F. Fatkullin Artur R. Akhmetgaliev Elena A. Vinokurova Ekaterina Yu. Aleynikova Olga A. Kuznetsova Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
description	Background. Abnormal uterine bleeding (AUB) occurs in one-third of women of reproductive age and has a significant impact on women's lives, causing anemia, impaired social adaptation and professional activity. AUB-O (ovulatory dysfunction) is often caused by an excessive body mass (BM) and obesity (especially visceral). The most effective option for restoring menstrual cycle (MC) in obese women is BM reduction. There is evidence that the combination of inositols myoinositol (MI) and D-chiroinositol (DCI) has a beneficial effect on BM loss, ovulation frequency and getting pregnant in women with polycystic ovary syndrome. Aim. To study the effect of MI and DHI in a 5:1 ratio in combination with diet and exercise on the regulation of MC in overweight and obese women. Materials and methods. The study has been conducted in clinics of Moscow, Kazan and Tyumen for 20202021. It is a descriptive study assessing an efficacy of lifestyle modification (diet and exercise) plus a nutritional support with a combination of 1000 mg MI and 200 mg DCI (ratio 5:1) for 24 months in 353 women of reproductive age with AMK-O and overweight or obesity. Efficacy criteria include: MC regularity, BM index (BMI), waist circumference (WC), levels of serum glucose, free testosterone, follicle-stimulating hormone, luteinizing hormone. Results. The study showed a significant shortening of MC to its physiological duration 3112.04 days (vs 4419.51 days at the 1st visit; p=0.001), a decrease in the rate of heavy bloody vaginal discharge by 2.57 times (p=0.001), an increase in the rate of moderate bloody vaginal discharge by 1,62 times (p=0.001), an increase in the proportion of patients with regular MC by 2.69 times (p=0.001). These changes were accompanied by a decrease in BM (-3 kg; p=0.001), a decrease in WC (-2.5 cm; p=0.001). Laboratory tests revealed a decrease in serum glucose (-1.3 mmol/L; p0.05), free testosterone (-0.4 pg/L; p0.05), luteinizing hormone (-0.8 mIU/ml; p0.05), and an increase in follicle-stimulating hormone (+0.1 mIU/ml; p0.05) levels. Conclusion. The results obtained (a decrease in BM, a decrease in BMI, WC, as well as MC restoration; p0.05) make it possible to recommend Dikirogen containing MI and DCI in a 5:1 ratio as a part of comprehensive therapy for overweight and obese women with AUB-O.
format	article
author	Alina V. Solovyeva Ildar F. Fatkullin Artur R. Akhmetgaliev Elena A. Vinokurova Ekaterina Yu. Aleynikova Olga A. Kuznetsova
author_facet	Alina V. Solovyeva Ildar F. Fatkullin Artur R. Akhmetgaliev Elena A. Vinokurova Ekaterina Yu. Aleynikova Olga A. Kuznetsova
author_sort	Alina V. Solovyeva
title	Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
title_short	Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
title_full	Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
title_fullStr	Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
title_full_unstemmed	Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
title_sort	comprehensive therapy with myoinositol and d-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/28a19c1785464b589fcd742d6e75dbd7
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Comprehensive therapy with myoinositol and D-chiroinositol in a 5:1 ratio for abnormal uterine bleeding in overweight and obese women

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