The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice

The transcriptional repressor Blimp1/PRDM1 regulates cell fate decisions in the developing embryo and adult tissues. Here the authors show that conditional inactivation within maternal uterine tissues results in a defective primary decidual zone barrier, increased expression of inflammatory cytokine...

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Autores principales: Mubeen Goolam, Maria-Eleni Xypolita, Ita Costello, John P. Lydon, Francesco J. DeMayo, Elizabeth K. Bikoff, Elizabeth J. Robertson, Arne W. Mould
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/28a1cda4aae6436bbc84b29955a20204
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spelling oai:doaj.org-article:28a1cda4aae6436bbc84b29955a202042021-12-02T15:56:39ZThe transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice10.1038/s41467-020-16603-z2041-1723https://doaj.org/article/28a1cda4aae6436bbc84b29955a202042020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16603-zhttps://doaj.org/toc/2041-1723The transcriptional repressor Blimp1/PRDM1 regulates cell fate decisions in the developing embryo and adult tissues. Here the authors show that conditional inactivation within maternal uterine tissues results in a defective primary decidual zone barrier, increased expression of inflammatory cytokines IFN gamma and Csf1, and early embryonic lethality during pregnancy.Mubeen GoolamMaria-Eleni XypolitaIta CostelloJohn P. LydonFrancesco J. DeMayoElizabeth K. BikoffElizabeth J. RobertsonArne W. MouldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mubeen Goolam
Maria-Eleni Xypolita
Ita Costello
John P. Lydon
Francesco J. DeMayo
Elizabeth K. Bikoff
Elizabeth J. Robertson
Arne W. Mould
The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
description The transcriptional repressor Blimp1/PRDM1 regulates cell fate decisions in the developing embryo and adult tissues. Here the authors show that conditional inactivation within maternal uterine tissues results in a defective primary decidual zone barrier, increased expression of inflammatory cytokines IFN gamma and Csf1, and early embryonic lethality during pregnancy.
format article
author Mubeen Goolam
Maria-Eleni Xypolita
Ita Costello
John P. Lydon
Francesco J. DeMayo
Elizabeth K. Bikoff
Elizabeth J. Robertson
Arne W. Mould
author_facet Mubeen Goolam
Maria-Eleni Xypolita
Ita Costello
John P. Lydon
Francesco J. DeMayo
Elizabeth K. Bikoff
Elizabeth J. Robertson
Arne W. Mould
author_sort Mubeen Goolam
title The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
title_short The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
title_full The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
title_fullStr The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
title_full_unstemmed The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice
title_sort transcriptional repressor blimp1/prdm1 regulates the maternal decidual response in mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/28a1cda4aae6436bbc84b29955a20204
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