DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Tet-transactivators are used for direct regulation of gene expression, RNA interference and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death in antigen-activated lymphocytes in vivo, putting into question the use of, and in vivo data gener...

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Autores principales:	Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J. Herold, Andreas Strasser, Andreas Villunger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28a3c17a5020441bb28ab5bc1d8548fa
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spelling	oai:doaj.org-article:28a3c17a5020441bb28ab5bc1d8548fa2021-12-02T17:01:18ZDNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice10.1038/s41467-017-01022-42041-1723https://doaj.org/article/28a3c17a5020441bb28ab5bc1d8548fa2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01022-4https://doaj.org/toc/2041-1723Tet-transactivators are used for direct regulation of gene expression, RNA interference and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death in antigen-activated lymphocytes in vivo, putting into question the use of, and in vivo data generated with, these molecular tools.Eleonora OttinaVictor PeperzakKatia SchoelerEmma CarringtonRoswitha SgoncMarc PellegriniSimon PrestonMarco J. HeroldAndreas StrasserAndreas VillungerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eleonora Ottina Victor Peperzak Katia Schoeler Emma Carrington Roswitha Sgonc Marc Pellegrini Simon Preston Marco J. Herold Andreas Strasser Andreas Villunger DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
description	Tet-transactivators are used for direct regulation of gene expression, RNA interference and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death in antigen-activated lymphocytes in vivo, putting into question the use of, and in vivo data generated with, these molecular tools.
format	article
author	Eleonora Ottina Victor Peperzak Katia Schoeler Emma Carrington Roswitha Sgonc Marc Pellegrini Simon Preston Marco J. Herold Andreas Strasser Andreas Villunger
author_facet	Eleonora Ottina Victor Peperzak Katia Schoeler Emma Carrington Roswitha Sgonc Marc Pellegrini Simon Preston Marco J. Herold Andreas Strasser Andreas Villunger
author_sort	Eleonora Ottina
title	DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
title_short	DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
title_full	DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
title_fullStr	DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
title_full_unstemmed	DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
title_sort	dna-binding of the tet-transactivator curtails antigen-induced lymphocyte activation in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/28a3c17a5020441bb28ab5bc1d8548fa
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DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

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