Historical contingencies modulate the adaptability of Rice yellow mottle virus.

The rymv1-2 and rymv1-3 alleles of the RYMV1 resistance to Rice yellow mottle virus (RYMV), coded by an eIF(iso)4G1 gene, occur in a few cultivars of the Asiatic (Oryza sativa) and African (O. glaberrima) rice species, respectively. The most salient feature of the resistance breaking (RB) process is...

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Autores principales:	Nils Poulicard, Agnès Pinel-Galzi, Oumar Traoré, Florence Vignols, Alain Ghesquière, Gnissa Konaté, Eugénie Hébrard, Denis Fargette
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/28a608e85262438991a1caa53c722074
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spelling	oai:doaj.org-article:28a608e85262438991a1caa53c7220742021-11-18T06:04:50ZHistorical contingencies modulate the adaptability of Rice yellow mottle virus.1553-73661553-737410.1371/journal.ppat.1002482https://doaj.org/article/28a608e85262438991a1caa53c7220742012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22291591/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The rymv1-2 and rymv1-3 alleles of the RYMV1 resistance to Rice yellow mottle virus (RYMV), coded by an eIF(iso)4G1 gene, occur in a few cultivars of the Asiatic (Oryza sativa) and African (O. glaberrima) rice species, respectively. The most salient feature of the resistance breaking (RB) process is the converse genetic barrier to rymv1-2 and rymv1-3 resistance breakdown. This specificity is modulated by the amino acid (glutamic acid vs. threonine) at codon 49 of the Viral Protein genome-linked (VPg), a position which is adjacent to the virulence codons 48 and 52. Isolates with a glutamic acid (E) do not overcome rymv1-3 whereas those with a threonine (T) rarely overcome rymv1-2. We found that isolates with T49 had a strong selective advantage over isolates with E49 in O. glaberrima susceptible cultivars. This explains the fixation of the mutation T49 during RYMV evolution and accounts for the diversifying selection estimated at codon 49. Better adapted to O. glaberrima, isolates with T49 are also more prone than isolates with E49 to fix rymv1-3 RB mutations at codon 52 in resistant O. glaberrima cultivars. However, subsequent genetic constraints impaired the ability of isolates with T49 to fix rymv1-2 RB mutations at codons 48 and 52 in resistant O. sativa cultivars. The origin and role of the amino acid at codon 49 of the VPg exemplifies the importance of historical contingencies in the ability of RYMV to overcome RYMV1 resistance.Nils PoulicardAgnès Pinel-GalziOumar TraoréFlorence VignolsAlain GhesquièreGnissa KonatéEugénie HébrardDenis FargettePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 1, p e1002482 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Nils Poulicard Agnès Pinel-Galzi Oumar Traoré Florence Vignols Alain Ghesquière Gnissa Konaté Eugénie Hébrard Denis Fargette Historical contingencies modulate the adaptability of Rice yellow mottle virus.
description	The rymv1-2 and rymv1-3 alleles of the RYMV1 resistance to Rice yellow mottle virus (RYMV), coded by an eIF(iso)4G1 gene, occur in a few cultivars of the Asiatic (Oryza sativa) and African (O. glaberrima) rice species, respectively. The most salient feature of the resistance breaking (RB) process is the converse genetic barrier to rymv1-2 and rymv1-3 resistance breakdown. This specificity is modulated by the amino acid (glutamic acid vs. threonine) at codon 49 of the Viral Protein genome-linked (VPg), a position which is adjacent to the virulence codons 48 and 52. Isolates with a glutamic acid (E) do not overcome rymv1-3 whereas those with a threonine (T) rarely overcome rymv1-2. We found that isolates with T49 had a strong selective advantage over isolates with E49 in O. glaberrima susceptible cultivars. This explains the fixation of the mutation T49 during RYMV evolution and accounts for the diversifying selection estimated at codon 49. Better adapted to O. glaberrima, isolates with T49 are also more prone than isolates with E49 to fix rymv1-3 RB mutations at codon 52 in resistant O. glaberrima cultivars. However, subsequent genetic constraints impaired the ability of isolates with T49 to fix rymv1-2 RB mutations at codons 48 and 52 in resistant O. sativa cultivars. The origin and role of the amino acid at codon 49 of the VPg exemplifies the importance of historical contingencies in the ability of RYMV to overcome RYMV1 resistance.
format	article
author	Nils Poulicard Agnès Pinel-Galzi Oumar Traoré Florence Vignols Alain Ghesquière Gnissa Konaté Eugénie Hébrard Denis Fargette
author_facet	Nils Poulicard Agnès Pinel-Galzi Oumar Traoré Florence Vignols Alain Ghesquière Gnissa Konaté Eugénie Hébrard Denis Fargette
author_sort	Nils Poulicard
title	Historical contingencies modulate the adaptability of Rice yellow mottle virus.
title_short	Historical contingencies modulate the adaptability of Rice yellow mottle virus.
title_full	Historical contingencies modulate the adaptability of Rice yellow mottle virus.
title_fullStr	Historical contingencies modulate the adaptability of Rice yellow mottle virus.
title_full_unstemmed	Historical contingencies modulate the adaptability of Rice yellow mottle virus.
title_sort	historical contingencies modulate the adaptability of rice yellow mottle virus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/28a608e85262438991a1caa53c722074
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Historical contingencies modulate the adaptability of Rice yellow mottle virus.

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