Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows

Abstract Background In highly intensive dairy farms, cows often suffer from metabolic disorders that cause severe oxidative stress. Objectives This study aimed to observe correlations and associations of oxidative stress‐related indicators with milk compositions and metabolites. Methods Twenty‐two m...

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Autores principales:	Sen Zheng, Guixin Qin, Yuguo Zhen, Xuefeng Zhang, Xue Chen, Jianan Dong, Chunlai Li, Natnael Demelash Aschalew, Tao Wang, Zhe Sun
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	antioxidants dairy cows metabolites reactive oxygen species Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/28ab3820fc624e2b911e79ee79db4af1
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spelling	oai:doaj.org-article:28ab3820fc624e2b911e79ee79db4af12021-11-19T17:14:25ZCorrelation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows2053-109510.1002/vms3.615https://doaj.org/article/28ab3820fc624e2b911e79ee79db4af12021-11-01T00:00:00Zhttps://doi.org/10.1002/vms3.615https://doaj.org/toc/2053-1095Abstract Background In highly intensive dairy farms, cows often suffer from metabolic disorders that cause severe oxidative stress. Objectives This study aimed to observe correlations and associations of oxidative stress‐related indicators with milk compositions and metabolites. Methods Twenty‐two multiparous Holstein dairy cows in early lactation were randomly selected from a commercial dairy farm. The morning milk was collected for composition and metabolites analysis. Blood was sampled via the tail vein to analyze oxidative stress‐related indicators (reactive oxygen species, ROS; catalase, CAT; superoxide dismutase, SOD; glutathione peroxidase, GPX; malondialdehyde, MDA) and metabolites. Results Results showed that ROS were positively correlated with CAT, GPX, SOD, and MDA. However, the levels of CAT, GPX, and SOD were negatively related to milk fat (P < 0.05). Nineteen serum and 7 milk metabolites were selected from detectable metabolites according to their correlations with ROS, CAT, GPX, and SOD (P < 0.05). Metabolic pathway analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed that these metabolites are primarily involved in the metabolic pathways of carbohydrates and amino acids. Conclusions This study gave us a better understanding on oxidative stress that ROS not only increased oxidative damage (MDA) in dairy cows, but also altered some metabolites involved in amino acid and carbohydrate metabolism.Sen ZhengGuixin QinYuguo ZhenXuefeng ZhangXue ChenJianan DongChunlai LiNatnael Demelash AschalewTao WangZhe SunWileyarticleantioxidantsdairy cowsmetabolitesreactive oxygen speciesVeterinary medicineSF600-1100ENVeterinary Medicine and Science, Vol 7, Iss 6, Pp 2250-2259 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidants dairy cows metabolites reactive oxygen species Veterinary medicine SF600-1100
spellingShingle	antioxidants dairy cows metabolites reactive oxygen species Veterinary medicine SF600-1100 Sen Zheng Guixin Qin Yuguo Zhen Xuefeng Zhang Xue Chen Jianan Dong Chunlai Li Natnael Demelash Aschalew Tao Wang Zhe Sun Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
description	Abstract Background In highly intensive dairy farms, cows often suffer from metabolic disorders that cause severe oxidative stress. Objectives This study aimed to observe correlations and associations of oxidative stress‐related indicators with milk compositions and metabolites. Methods Twenty‐two multiparous Holstein dairy cows in early lactation were randomly selected from a commercial dairy farm. The morning milk was collected for composition and metabolites analysis. Blood was sampled via the tail vein to analyze oxidative stress‐related indicators (reactive oxygen species, ROS; catalase, CAT; superoxide dismutase, SOD; glutathione peroxidase, GPX; malondialdehyde, MDA) and metabolites. Results Results showed that ROS were positively correlated with CAT, GPX, SOD, and MDA. However, the levels of CAT, GPX, and SOD were negatively related to milk fat (P < 0.05). Nineteen serum and 7 milk metabolites were selected from detectable metabolites according to their correlations with ROS, CAT, GPX, and SOD (P < 0.05). Metabolic pathway analysis and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed that these metabolites are primarily involved in the metabolic pathways of carbohydrates and amino acids. Conclusions This study gave us a better understanding on oxidative stress that ROS not only increased oxidative damage (MDA) in dairy cows, but also altered some metabolites involved in amino acid and carbohydrate metabolism.
format	article
author	Sen Zheng Guixin Qin Yuguo Zhen Xuefeng Zhang Xue Chen Jianan Dong Chunlai Li Natnael Demelash Aschalew Tao Wang Zhe Sun
author_facet	Sen Zheng Guixin Qin Yuguo Zhen Xuefeng Zhang Xue Chen Jianan Dong Chunlai Li Natnael Demelash Aschalew Tao Wang Zhe Sun
author_sort	Sen Zheng
title	Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
title_short	Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
title_full	Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
title_fullStr	Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
title_full_unstemmed	Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
title_sort	correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/28ab3820fc624e2b911e79ee79db4af1
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_version_	1718420001060290560

Correlation of oxidative stress‐related indicators with milk composition and metabolites in early lactating dairy cows

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