Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain

Frequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such arousals are often short, partial, or occur locally within the brain, reliable characterization in rodent models of sleep disorders and in human patients is challenging. We found that the EE...

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Autores principales:	Romain Cardis, Sandro Lecci, Laura MJ Fernandez, Alejandro Osorio-Forero, Paul Chu Sin Chung, Stephany Fulda, Isabelle Decosterd, Anita Lüthi
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	NREMS spared-nerve-injury arousal insomnia gamma power infraslow Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/28abc20eae404569a2555de416268c09
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spelling	oai:doaj.org-article:28abc20eae404569a2555de416268c092021-11-16T14:03:05ZCortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain10.7554/eLife.658352050-084Xe65835https://doaj.org/article/28abc20eae404569a2555de416268c092021-07-01T00:00:00Zhttps://elifesciences.org/articles/65835https://doaj.org/toc/2050-084XFrequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such arousals are often short, partial, or occur locally within the brain, reliable characterization in rodent models of sleep disorders and in human patients is challenging. We found that the EEG spectral composition of non-rapid eye movement sleep (NREMS) in healthy mice shows an infraslow (~50 s) interval over which microarousals appear preferentially. NREMS could hence be vulnerable to abnormal arousals on this time scale. Chronic pain is well-known to disrupt sleep. In the spared nerve injury (SNI) mouse model of chronic neuropathic pain, we found more numerous local cortical arousals accompanied by heart rate increases in hindlimb primary somatosensory, but not in prelimbic, cortices, although sleep macroarchitecture appeared unaltered. Closed-loop mechanovibrational stimulation further revealed higher sensory arousability. Chronic pain thus preserved conventional sleep measures but resulted in elevated spontaneous and evoked arousability. We develop a novel moment-to-moment probing of NREMS vulnerability and propose that chronic pain-induced sleep complaints arise from perturbed arousability.Romain CardisSandro LecciLaura MJ FernandezAlejandro Osorio-ForeroPaul Chu Sin ChungStephany FuldaIsabelle DecosterdAnita LüthieLife Sciences Publications LtdarticleNREMSspared-nerve-injuryarousalinsomniagamma powerinfraslowMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NREMS spared-nerve-injury arousal insomnia gamma power infraslow Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	NREMS spared-nerve-injury arousal insomnia gamma power infraslow Medicine R Science Q Biology (General) QH301-705.5 Romain Cardis Sandro Lecci Laura MJ Fernandez Alejandro Osorio-Forero Paul Chu Sin Chung Stephany Fulda Isabelle Decosterd Anita Lüthi Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain
description	Frequent nightly arousals typical for sleep disorders cause daytime fatigue and present health risks. As such arousals are often short, partial, or occur locally within the brain, reliable characterization in rodent models of sleep disorders and in human patients is challenging. We found that the EEG spectral composition of non-rapid eye movement sleep (NREMS) in healthy mice shows an infraslow (~50 s) interval over which microarousals appear preferentially. NREMS could hence be vulnerable to abnormal arousals on this time scale. Chronic pain is well-known to disrupt sleep. In the spared nerve injury (SNI) mouse model of chronic neuropathic pain, we found more numerous local cortical arousals accompanied by heart rate increases in hindlimb primary somatosensory, but not in prelimbic, cortices, although sleep macroarchitecture appeared unaltered. Closed-loop mechanovibrational stimulation further revealed higher sensory arousability. Chronic pain thus preserved conventional sleep measures but resulted in elevated spontaneous and evoked arousability. We develop a novel moment-to-moment probing of NREMS vulnerability and propose that chronic pain-induced sleep complaints arise from perturbed arousability.
format	article
author	Romain Cardis Sandro Lecci Laura MJ Fernandez Alejandro Osorio-Forero Paul Chu Sin Chung Stephany Fulda Isabelle Decosterd Anita Lüthi
author_facet	Romain Cardis Sandro Lecci Laura MJ Fernandez Alejandro Osorio-Forero Paul Chu Sin Chung Stephany Fulda Isabelle Decosterd Anita Lüthi
author_sort	Romain Cardis
title	Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain
title_short	Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain
title_full	Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain
title_fullStr	Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain
title_full_unstemmed	Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain
title_sort	cortico-autonomic local arousals and heightened somatosensory arousability during nrems of mice in neuropathic pain
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/28abc20eae404569a2555de416268c09
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Cortico-autonomic local arousals and heightened somatosensory arousability during NREMS of mice in neuropathic pain

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