Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs

Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs

Nse2 is a SUMO E3 ligase component of the Smc5/6 multisubunit complex involved in the DNA repair and chromosome integrity. Here, the structure of the Nse2 in complex with an E2-SUMO thioester mimetic reveals the combined action of two SIM motifs during the E3- dependent conjugation reaction.

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Autores principales: Nathalia Varejão, Jara Lascorz, Joan Codina-Fabra, Gemma Bellí, Helena Borràs-Gas, Jordi Torres-Rosell, David Reverter
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/28ad71f30e934e4999a0f81c683279e0
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spelling oai:doaj.org-article:28ad71f30e934e4999a0f81c683279e02021-12-05T12:22:46ZStructural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs10.1038/s41467-021-27301-92041-1723https://doaj.org/article/28ad71f30e934e4999a0f81c683279e02021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27301-9https://doaj.org/toc/2041-1723Nse2 is a SUMO E3 ligase component of the Smc5/6 multisubunit complex involved in the DNA repair and chromosome integrity. Here, the structure of the Nse2 in complex with an E2-SUMO thioester mimetic reveals the combined action of two SIM motifs during the E3- dependent conjugation reaction.Nathalia VarejãoJara LascorzJoan Codina-FabraGemma BellíHelena Borràs-GasJordi Torres-RosellDavid ReverterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Nathalia Varejão
Jara Lascorz
Joan Codina-Fabra
Gemma Bellí
Helena Borràs-Gas
Jordi Torres-Rosell
David Reverter
Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
description Nse2 is a SUMO E3 ligase component of the Smc5/6 multisubunit complex involved in the DNA repair and chromosome integrity. Here, the structure of the Nse2 in complex with an E2-SUMO thioester mimetic reveals the combined action of two SIM motifs during the E3- dependent conjugation reaction.
format article
author Nathalia Varejão
Jara Lascorz
Joan Codina-Fabra
Gemma Bellí
Helena Borràs-Gas
Jordi Torres-Rosell
David Reverter
author_facet Nathalia Varejão
Jara Lascorz
Joan Codina-Fabra
Gemma Bellí
Helena Borràs-Gas
Jordi Torres-Rosell
David Reverter
author_sort Nathalia Varejão
title Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
title_short Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
title_full Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
title_fullStr Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
title_full_unstemmed Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs
title_sort structural basis for the e3 ligase activity enhancement of yeast nse2 by sumo-interacting motifs
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/28ad71f30e934e4999a0f81c683279e0
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AT helenaborrasgas structuralbasisforthee3ligaseactivityenhancementofyeastnse2bysumointeractingmotifs
AT jorditorresrosell structuralbasisforthee3ligaseactivityenhancementofyeastnse2bysumointeractingmotifs
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