Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium

AIM: To observe the curative effect of pterygium resection and autologous limbal stem cell transplantation(LSCT)combined with amniotic membrane transplantation(AMT)in the treatment of pterygium.METHODS: Totally 177 patients(187 eyes)with pterygium treated in ophthalmology clinic of the hospital betw...

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Autores principales:	Yan-Xi Wang, Juan Zhou, Ying Chen, Min Wang, Gang-Jin Kang
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	pterygium autologous limbal stem cell transplantation amniotic membrane transplantation curative effect corneal epithelium corneal neovascularization Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/28b2ac5166224b4c91709329b00ad83f
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spelling	oai:doaj.org-article:28b2ac5166224b4c91709329b00ad83f2021-11-22T14:22:33ZCurative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium1672-512310.3980/j.issn.1672-5123.2021.12.26https://doaj.org/article/28b2ac5166224b4c91709329b00ad83f2021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112026.pdfhttps://doaj.org/toc/1672-5123AIM: To observe the curative effect of pterygium resection and autologous limbal stem cell transplantation(LSCT)combined with amniotic membrane transplantation(AMT)in the treatment of pterygium.METHODS: Totally 177 patients(187 eyes)with pterygium treated in ophthalmology clinic of the hospital between January 2017 and January 2020 were selected and randomly divided into group A(59 cases, 64 eyes), group B(59 cases, 60 eyes), and group C(59 cases, 63 eyes). All were treated with pterygium resection. On this basis, patients in the three groups were treated with autologous LSCT, AMT, and autologous LSCT combined with AMT, respectively. All subjects were followed up for 12mo after surgery. Visual acuity, corneal epithelial repair, and neovascularization of the three groups were comparatively analyzed. Postoperative recurrence rate, ocular symptoms, complications, and survival of grafts were statistically analyzed.RESULTS: Visual acuity changes and repair time of corneal epithelial defect showed no statistically significant difference among the three groups(P>0.05). 1mo after surgery, the corneal fluorescein staining(FL)value of group C was significantly lower than that of group A or group B(all P<0.05). No angiogenesis or recurrent true pterygium was observed. 6mo and 12mo after surgery, the grades of conjunctival fibroplasia in group A and group C were significantly different from that in group B(P<0.05). There was no statistically significant difference in the wet length of the filter paper in Schirmer I test in terms of time, inter-group and interaction effects(P>0.05). 1mo after surgery, the tear film breakup time(BUT)of group C was significantly longer than that of group A or group B(all P<0.05). There were different degrees of conjunctival edema in the three groups after surgery, which disappeared within 2wk after suture removal. Grafts all survived, vascularization of amniotic membrane grafts ended.CONCLUSION:Autologous LSCT, AMT and autologous LSCT combined with AMT all are effective in the treatment of pterygium. However, autologous LSCT combined with AMT can achieve better short-term effect, with milder conjunctival fibroplasia and dry eye symptoms.Yan-Xi WangJuan ZhouYing ChenMin WangYing ChenGang-Jin KangPress of International Journal of Ophthalmology (IJO PRESS)articlepterygiumautologous limbal stem cell transplantationamniotic membrane transplantationcurative effectcorneal epitheliumcorneal neovascularizationOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2156-2160 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pterygium autologous limbal stem cell transplantation amniotic membrane transplantation curative effect corneal epithelium corneal neovascularization Ophthalmology RE1-994
spellingShingle	pterygium autologous limbal stem cell transplantation amniotic membrane transplantation curative effect corneal epithelium corneal neovascularization Ophthalmology RE1-994 Yan-Xi Wang Juan Zhou Ying Chen Min Wang Ying Chen Gang-Jin Kang Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
description	AIM: To observe the curative effect of pterygium resection and autologous limbal stem cell transplantation(LSCT)combined with amniotic membrane transplantation(AMT)in the treatment of pterygium.METHODS: Totally 177 patients(187 eyes)with pterygium treated in ophthalmology clinic of the hospital between January 2017 and January 2020 were selected and randomly divided into group A(59 cases, 64 eyes), group B(59 cases, 60 eyes), and group C(59 cases, 63 eyes). All were treated with pterygium resection. On this basis, patients in the three groups were treated with autologous LSCT, AMT, and autologous LSCT combined with AMT, respectively. All subjects were followed up for 12mo after surgery. Visual acuity, corneal epithelial repair, and neovascularization of the three groups were comparatively analyzed. Postoperative recurrence rate, ocular symptoms, complications, and survival of grafts were statistically analyzed.RESULTS: Visual acuity changes and repair time of corneal epithelial defect showed no statistically significant difference among the three groups(P>0.05). 1mo after surgery, the corneal fluorescein staining(FL)value of group C was significantly lower than that of group A or group B(all P<0.05). No angiogenesis or recurrent true pterygium was observed. 6mo and 12mo after surgery, the grades of conjunctival fibroplasia in group A and group C were significantly different from that in group B(P<0.05). There was no statistically significant difference in the wet length of the filter paper in Schirmer I test in terms of time, inter-group and interaction effects(P>0.05). 1mo after surgery, the tear film breakup time(BUT)of group C was significantly longer than that of group A or group B(all P<0.05). There were different degrees of conjunctival edema in the three groups after surgery, which disappeared within 2wk after suture removal. Grafts all survived, vascularization of amniotic membrane grafts ended.CONCLUSION:Autologous LSCT, AMT and autologous LSCT combined with AMT all are effective in the treatment of pterygium. However, autologous LSCT combined with AMT can achieve better short-term effect, with milder conjunctival fibroplasia and dry eye symptoms.
format	article
author	Yan-Xi Wang Juan Zhou Ying Chen Min Wang Ying Chen Gang-Jin Kang
author_facet	Yan-Xi Wang Juan Zhou Ying Chen Min Wang Ying Chen Gang-Jin Kang
author_sort	Yan-Xi Wang
title	Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
title_short	Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
title_full	Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
title_fullStr	Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
title_full_unstemmed	Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
title_sort	curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/28b2ac5166224b4c91709329b00ad83f
work_keys_str_mv	AT yanxiwang curativeeffectofpterygiumresectionandautologouslimbalstemcelltransplantationcombinedwithamnioticmembranetransplantationinthetreatmentofpterygium AT juanzhou curativeeffectofpterygiumresectionandautologouslimbalstemcelltransplantationcombinedwithamnioticmembranetransplantationinthetreatmentofpterygium AT yingchen curativeeffectofpterygiumresectionandautologouslimbalstemcelltransplantationcombinedwithamnioticmembranetransplantationinthetreatmentofpterygium AT minwang curativeeffectofpterygiumresectionandautologouslimbalstemcelltransplantationcombinedwithamnioticmembranetransplantationinthetreatmentofpterygium AT yingchen curativeeffectofpterygiumresectionandautologouslimbalstemcelltransplantationcombinedwithamnioticmembranetransplantationinthetreatmentofpterygium AT gangjinkang curativeeffectofpterygiumresectionandautologouslimbalstemcelltransplantationcombinedwithamnioticmembranetransplantationinthetreatmentofpterygium
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Curative effect of pterygium resection and autologous limbal stem cell transplantation combined with amniotic membrane transplantation in the treatment of pterygium

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