Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

Favipiravir has broad-spectrum antiviral activity against a variety of RNA viruses. Here the authors investigate the safety, pharmacokinetics and anti-SARS-CoV-2 efficacy of different drug dosage in the a Syrian hamster model of infection and, combined with genetic analyses, they show that Favipirav...

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Autores principales: Jean-Sélim Driouich, Maxime Cochin, Guillaume Lingas, Grégory Moureau, Franck Touret, Paul-Rémi Petit, Géraldine Piorkowski, Karine Barthélémy, Caroline Laprie, Bruno Coutard, Jérémie Guedj, Xavier de Lamballerie, Caroline Solas, Antoine Nougairède
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/28b65fe72e8643d09a5316e736cd7471
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spelling oai:doaj.org-article:28b65fe72e8643d09a5316e736cd74712021-12-02T13:17:59ZFavipiravir antiviral efficacy against SARS-CoV-2 in a hamster model10.1038/s41467-021-21992-w2041-1723https://doaj.org/article/28b65fe72e8643d09a5316e736cd74712021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21992-whttps://doaj.org/toc/2041-1723Favipiravir has broad-spectrum antiviral activity against a variety of RNA viruses. Here the authors investigate the safety, pharmacokinetics and anti-SARS-CoV-2 efficacy of different drug dosage in the a Syrian hamster model of infection and, combined with genetic analyses, they show that Favipiravir at high doses decrease viral infectivity while inducing the emergence of mutations in viral genomes, decreasing fitness.Jean-Sélim DriouichMaxime CochinGuillaume LingasGrégory MoureauFranck TouretPaul-Rémi PetitGéraldine PiorkowskiKarine BarthélémyCaroline LaprieBruno CoutardJérémie GuedjXavier de LamballerieCaroline SolasAntoine NougairèdeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jean-Sélim Driouich
Maxime Cochin
Guillaume Lingas
Grégory Moureau
Franck Touret
Paul-Rémi Petit
Géraldine Piorkowski
Karine Barthélémy
Caroline Laprie
Bruno Coutard
Jérémie Guedj
Xavier de Lamballerie
Caroline Solas
Antoine Nougairède
Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
description Favipiravir has broad-spectrum antiviral activity against a variety of RNA viruses. Here the authors investigate the safety, pharmacokinetics and anti-SARS-CoV-2 efficacy of different drug dosage in the a Syrian hamster model of infection and, combined with genetic analyses, they show that Favipiravir at high doses decrease viral infectivity while inducing the emergence of mutations in viral genomes, decreasing fitness.
format article
author Jean-Sélim Driouich
Maxime Cochin
Guillaume Lingas
Grégory Moureau
Franck Touret
Paul-Rémi Petit
Géraldine Piorkowski
Karine Barthélémy
Caroline Laprie
Bruno Coutard
Jérémie Guedj
Xavier de Lamballerie
Caroline Solas
Antoine Nougairède
author_facet Jean-Sélim Driouich
Maxime Cochin
Guillaume Lingas
Grégory Moureau
Franck Touret
Paul-Rémi Petit
Géraldine Piorkowski
Karine Barthélémy
Caroline Laprie
Bruno Coutard
Jérémie Guedj
Xavier de Lamballerie
Caroline Solas
Antoine Nougairède
author_sort Jean-Sélim Driouich
title Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
title_short Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
title_full Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
title_fullStr Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
title_full_unstemmed Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model
title_sort favipiravir antiviral efficacy against sars-cov-2 in a hamster model
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/28b65fe72e8643d09a5316e736cd7471
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