The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus

Results of numerous studies give definitive evidence that phenofibrate affects activity of PPAR-a receptors in liver and thereby decreases the level oflipids responsible for the development of atherosclerosis (VLDL, small dense LDL); simultaneously, it increases the level of anti-atherogenic HDL.Act...

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Main Authors:	Larisa Viktorovna Koshel', Tatiana Ivanovna Romantsova
Format:	article
Language:	EN RU
Published:	Endocrinology Research Centre 2009
Subjects:	phenofibrate retinopathy neuropathy diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
Online Access:	https://doaj.org/article/28b800a6fc9641ab9b439ccb4e17d1c4
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spelling	oai:doaj.org-article:28b800a6fc9641ab9b439ccb4e17d1c42021-11-14T09:00:14ZThe role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-5714https://doaj.org/article/28b800a6fc9641ab9b439ccb4e17d1c42009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5714https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Results of numerous studies give definitive evidence that phenofibrate affects activity of PPAR-a receptors in liver and thereby decreases the level oflipids responsible for the development of atherosclerosis (VLDL, small dense LDL); simultaneously, it increases the level of anti-atherogenic HDL.Activation of PPAR-a receptors in vascular cells decreases activity of inflammation markers, such as C-reactive protein, TNF-a, IL-6, fibrinogen,etc. These effects of phenofibrate eventually lead to reduced risk of macro- and microvascular diabetic complications.Larisa Viktorovna Koshel'Tatiana Ivanovna RomantsovaEndocrinology Research Centrearticlephenofibrateretinopathyneuropathydiabetes mellitusNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 99-103 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	phenofibrate retinopathy neuropathy diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	phenofibrate retinopathy neuropathy diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 Larisa Viktorovna Koshel' Tatiana Ivanovna Romantsova The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
description	Results of numerous studies give definitive evidence that phenofibrate affects activity of PPAR-a receptors in liver and thereby decreases the level oflipids responsible for the development of atherosclerosis (VLDL, small dense LDL); simultaneously, it increases the level of anti-atherogenic HDL.Activation of PPAR-a receptors in vascular cells decreases activity of inflammation markers, such as C-reactive protein, TNF-a, IL-6, fibrinogen,etc. These effects of phenofibrate eventually lead to reduced risk of macro- and microvascular diabetic complications.
format	article
author	Larisa Viktorovna Koshel' Tatiana Ivanovna Romantsova
author_facet	Larisa Viktorovna Koshel' Tatiana Ivanovna Romantsova
author_sort	Larisa Viktorovna Koshel'
title	The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
title_short	The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
title_full	The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
title_fullStr	The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
title_full_unstemmed	The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
title_sort	role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/28b800a6fc9641ab9b439ccb4e17d1c4
work_keys_str_mv	AT larisaviktorovnakoshel theroleofphenofibrateinthetreatmentofmicrovascularcomplicationsoftype2diabetesmellitus AT tatianaivanovnaromantsova theroleofphenofibrateinthetreatmentofmicrovascularcomplicationsoftype2diabetesmellitus AT larisaviktorovnakoshel roleofphenofibrateinthetreatmentofmicrovascularcomplicationsoftype2diabetesmellitus AT tatianaivanovnaromantsova roleofphenofibrateinthetreatmentofmicrovascularcomplicationsoftype2diabetesmellitus
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The role of phenofibrate in the treatment of microvascular complications of type 2 diabetes mellitus

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