Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Abstract Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk facto...

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Autores principales:	E. García-Escobar, S. Valdés, F. Soriguer, J. Vendrell, I. M. Urrutia-Etxebarria, C. Maldonado-Araque, E. Ortega, P. Ocón, E. Montanya, E. Menéndez, A. Lago-Sampedro, T. González-Frutos, R. Gomis, A. Goday, S. García-Serrano, J. L. Galán-García, C. Castell, E. Bordiú, R. Badía, G. Aguilera-Venegas, J. Girbés, S. Gaztambide, E. Delgado, F. J. Chaves, L. Castaño, A. Calle-Pascual, G. Rojo-Martínez, J. Franch-Nadal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28b84e6f83be4b6e8c242034dfc860aa
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spelling	oai:doaj.org-article:28b84e6f83be4b6e8c242034dfc860aa2021-12-02T16:43:38ZFatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study10.1038/s41598-021-95546-x2045-2322https://doaj.org/article/28b84e6f83be4b6e8c242034dfc860aa2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95546-xhttps://doaj.org/toc/2045-2322Abstract Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the Di@bet.es cohort study were studied. Socio-demographic, anthropometric, clinical data and survey on habits were recorded. An oral glucose tolerance test was performed and fasting determinations of glucose, lipids and insulin were made. FLI was calculated and classified into three categories: Low (< 30), intermediate (30–60) and high (> 60). In total, 143 people developed diabetes at follow-up. The presence of a high FLI category was in all cases a significant independent risk factor for the development of diabetes. The inclusion of FLI categories in prediction models based on different conventional T2DM risk factors significantly increase the prediction power of the models when all the population was considered. According to our results, FLI might be considered an early indicator of T2DM development even under normoglycemic condition. The data also suggest that FLI could provide additional information for the prediction of T2DM in models based on conventional risk factors.E. García-EscobarS. ValdésF. SoriguerJ. VendrellI. M. Urrutia-EtxebarriaC. Maldonado-AraqueE. OrtegaP. OcónE. MontanyaE. MenéndezA. Lago-SampedroT. González-FrutosR. GomisA. GodayS. García-SerranoJ. L. Galán-GarcíaC. CastellE. BordiúR. BadíaG. Aguilera-VenegasJ. GirbésS. GaztambideE. DelgadoF. J. ChavesL. CastañoA. Calle-PascualG. Rojo-MartínezJ. Franch-NadalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q E. García-Escobar S. Valdés F. Soriguer J. Vendrell I. M. Urrutia-Etxebarria C. Maldonado-Araque E. Ortega P. Ocón E. Montanya E. Menéndez A. Lago-Sampedro T. González-Frutos R. Gomis A. Goday S. García-Serrano J. L. Galán-García C. Castell E. Bordiú R. Badía G. Aguilera-Venegas J. Girbés S. Gaztambide E. Delgado F. J. Chaves L. Castaño A. Calle-Pascual G. Rojo-Martínez J. Franch-Nadal Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
description	Abstract Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the Di@bet.es cohort study were studied. Socio-demographic, anthropometric, clinical data and survey on habits were recorded. An oral glucose tolerance test was performed and fasting determinations of glucose, lipids and insulin were made. FLI was calculated and classified into three categories: Low (< 30), intermediate (30–60) and high (> 60). In total, 143 people developed diabetes at follow-up. The presence of a high FLI category was in all cases a significant independent risk factor for the development of diabetes. The inclusion of FLI categories in prediction models based on different conventional T2DM risk factors significantly increase the prediction power of the models when all the population was considered. According to our results, FLI might be considered an early indicator of T2DM development even under normoglycemic condition. The data also suggest that FLI could provide additional information for the prediction of T2DM in models based on conventional risk factors.
format	article
author	E. García-Escobar S. Valdés F. Soriguer J. Vendrell I. M. Urrutia-Etxebarria C. Maldonado-Araque E. Ortega P. Ocón E. Montanya E. Menéndez A. Lago-Sampedro T. González-Frutos R. Gomis A. Goday S. García-Serrano J. L. Galán-García C. Castell E. Bordiú R. Badía G. Aguilera-Venegas J. Girbés S. Gaztambide E. Delgado F. J. Chaves L. Castaño A. Calle-Pascual G. Rojo-Martínez J. Franch-Nadal
author_facet	E. García-Escobar S. Valdés F. Soriguer J. Vendrell I. M. Urrutia-Etxebarria C. Maldonado-Araque E. Ortega P. Ocón E. Montanya E. Menéndez A. Lago-Sampedro T. González-Frutos R. Gomis A. Goday S. García-Serrano J. L. Galán-García C. Castell E. Bordiú R. Badía G. Aguilera-Venegas J. Girbés S. Gaztambide E. Delgado F. J. Chaves L. Castaño A. Calle-Pascual G. Rojo-Martínez J. Franch-Nadal
author_sort	E. García-Escobar
title	Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
title_short	Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
title_full	Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
title_fullStr	Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
title_full_unstemmed	Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
title_sort	fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28b84e6f83be4b6e8c242034dfc860aa
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Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

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