Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.

This study aimed to evaluate the effects of epidural anaesthesia with lidocaine in combination with general anaesthesia with propofol on some immunologic indices in dogs undergoing ovariohysterectomy. Twelve adult dogs were anesthetized with propofol (induction: 7 mg/kg; maintenance: 0.4 mg/kg/min)...

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Autores principales:	Hadi Imani Rastabi, Mohammad Khosravi, Reza Avizeh, Maryam Moslemi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28be196cc5e74d3bbdde4f3ab553ce2b
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spelling	oai:doaj.org-article:28be196cc5e74d3bbdde4f3ab553ce2b2021-12-02T20:09:54ZEvaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.1932-620310.1371/journal.pone.0253731https://doaj.org/article/28be196cc5e74d3bbdde4f3ab553ce2b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253731https://doaj.org/toc/1932-6203This study aimed to evaluate the effects of epidural anaesthesia with lidocaine in combination with general anaesthesia with propofol on some immunologic indices in dogs undergoing ovariohysterectomy. Twelve adult dogs were anesthetized with propofol (induction: 7 mg/kg; maintenance: 0.4 mg/kg/min) and were then allocated into either groups of epidural saline (control) or epidural lidocaine (4 mg/kg; treatment). All the included animals underwent ovariohysterectomy operation. The immune responses, hematologic parameters and cortisol levels were assessed in the predetermined intervals. Evaluation of the innate immunity revealed higher significant levels in the bactericidal, lysozyme and myeloperoxidase activities at 4 hours after surgery in the treatment. In the humoral immunity, the total immunoglobulin level was significantly higher in the treatment. In the assessment of cellular immunity, higher significant values were detected in the delayed skin sensitivity to phytohemagglutinine injection after 48 and 72 hours in the treatment. Moreover, higher significant levels were observed in the number and percentage of lymphocytes as well as an increase in the percentage of monocytes in the treatment at 4 hours after the operation. Notably, the cortisol hormone in the treatment was lower than control at 4 hours of the surgery. In conclusion, epidural anaesthesia with lidocaine when added to general anaesthesia with propofol attenuated the suppression of the innate and cellular immune responses produced by anaesthesia and surgery in the dogs.Hadi Imani RastabiMohammad KhosraviReza AvizehMaryam MoslemiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253731 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hadi Imani Rastabi Mohammad Khosravi Reza Avizeh Maryam Moslemi Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
description	This study aimed to evaluate the effects of epidural anaesthesia with lidocaine in combination with general anaesthesia with propofol on some immunologic indices in dogs undergoing ovariohysterectomy. Twelve adult dogs were anesthetized with propofol (induction: 7 mg/kg; maintenance: 0.4 mg/kg/min) and were then allocated into either groups of epidural saline (control) or epidural lidocaine (4 mg/kg; treatment). All the included animals underwent ovariohysterectomy operation. The immune responses, hematologic parameters and cortisol levels were assessed in the predetermined intervals. Evaluation of the innate immunity revealed higher significant levels in the bactericidal, lysozyme and myeloperoxidase activities at 4 hours after surgery in the treatment. In the humoral immunity, the total immunoglobulin level was significantly higher in the treatment. In the assessment of cellular immunity, higher significant values were detected in the delayed skin sensitivity to phytohemagglutinine injection after 48 and 72 hours in the treatment. Moreover, higher significant levels were observed in the number and percentage of lymphocytes as well as an increase in the percentage of monocytes in the treatment at 4 hours after the operation. Notably, the cortisol hormone in the treatment was lower than control at 4 hours of the surgery. In conclusion, epidural anaesthesia with lidocaine when added to general anaesthesia with propofol attenuated the suppression of the innate and cellular immune responses produced by anaesthesia and surgery in the dogs.
format	article
author	Hadi Imani Rastabi Mohammad Khosravi Reza Avizeh Maryam Moslemi
author_facet	Hadi Imani Rastabi Mohammad Khosravi Reza Avizeh Maryam Moslemi
author_sort	Hadi Imani Rastabi
title	Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
title_short	Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
title_full	Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
title_fullStr	Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
title_full_unstemmed	Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
title_sort	evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/28be196cc5e74d3bbdde4f3ab553ce2b
work_keys_str_mv	AT hadiimanirastabi evaluationoftheeffectoflidocaineepiduralinjectiononimmunologicalindicesindogsundertotalintravenousanesthesiasubmittedtoovariohysterectomy AT mohammadkhosravi evaluationoftheeffectoflidocaineepiduralinjectiononimmunologicalindicesindogsundertotalintravenousanesthesiasubmittedtoovariohysterectomy AT rezaavizeh evaluationoftheeffectoflidocaineepiduralinjectiononimmunologicalindicesindogsundertotalintravenousanesthesiasubmittedtoovariohysterectomy AT maryammoslemi evaluationoftheeffectoflidocaineepiduralinjectiononimmunologicalindicesindogsundertotalintravenousanesthesiasubmittedtoovariohysterectomy
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Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy.

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