A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

A novel hotspot of gelsolin instability triggers an alternative mechanism of amyloid aggregation

Gelsolin comprises six homologous domains, named G1 to G6. Single point substitutions in this protein are responsible for AGel amyloidosis, a hereditary disease causing progressive corneal lattice dystrophy, cutis laxa, and polyneuropathy. Although several different amyloidogenic variants of gelsoli...

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Main Authors: Michela Bollati, Luisa Diomede, Toni Giorgino, Carmina Natale, Elisa Fagnani, Irene Boniardi, Alberto Barbiroli, Rebecca Alemani, Marten Beeg, Marco Gobbi, Ana Fakin, Eloise Mastrangelo, Mario Milani, Gianluca Presciuttini, Edi Gabellieri, Patrizia Cioni, Matteo de Rosa
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Amyloidosis
C. elegans
Gelsolin
Misfolding
Pathogenic variant
Biotechnology
TP248.13-248.65
Online Access:https://doaj.org/article/28c0fa7cd36a48168031138ec41efe6d
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https://doaj.org/article/28c0fa7cd36a48168031138ec41efe6d

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