In situ structure and assembly of the multidrug efflux pump AcrAB-TolC

In situ structure and assembly of the multidrug efflux pump AcrAB-TolC

Multidrug efflux pumps actively expel a wide range of toxic substrates from bacteria and play a major role in drug resistance. Here authors show the in situ structure of the efflux pump AcrAB-TolC obtained by electron cryo-tomography and subtomogram averaging.

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Autores principales: Xiaodong Shi, Muyuan Chen, Zhili Yu, James M. Bell, Hans Wang, Isaac Forrester, Heather Villarreal, Joanita Jakana, Dijun Du, Ben F. Luisi, Steven J. Ludtke, Zhao Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/28c29f6371ef4ce0931bd60ea29799b1
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spelling oai:doaj.org-article:28c29f6371ef4ce0931bd60ea29799b12021-12-02T15:36:06ZIn situ structure and assembly of the multidrug efflux pump AcrAB-TolC10.1038/s41467-019-10512-62041-1723https://doaj.org/article/28c29f6371ef4ce0931bd60ea29799b12019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10512-6https://doaj.org/toc/2041-1723Multidrug efflux pumps actively expel a wide range of toxic substrates from bacteria and play a major role in drug resistance. Here authors show the in situ structure of the efflux pump AcrAB-TolC obtained by electron cryo-tomography and subtomogram averaging.Xiaodong ShiMuyuan ChenZhili YuJames M. BellHans WangIsaac ForresterHeather VillarrealJoanita JakanaDijun DuBen F. LuisiSteven J. LudtkeZhao WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaodong Shi
Muyuan Chen
Zhili Yu
James M. Bell
Hans Wang
Isaac Forrester
Heather Villarreal
Joanita Jakana
Dijun Du
Ben F. Luisi
Steven J. Ludtke
Zhao Wang
In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
description Multidrug efflux pumps actively expel a wide range of toxic substrates from bacteria and play a major role in drug resistance. Here authors show the in situ structure of the efflux pump AcrAB-TolC obtained by electron cryo-tomography and subtomogram averaging.
format article
author Xiaodong Shi
Muyuan Chen
Zhili Yu
James M. Bell
Hans Wang
Isaac Forrester
Heather Villarreal
Joanita Jakana
Dijun Du
Ben F. Luisi
Steven J. Ludtke
Zhao Wang
author_facet Xiaodong Shi
Muyuan Chen
Zhili Yu
James M. Bell
Hans Wang
Isaac Forrester
Heather Villarreal
Joanita Jakana
Dijun Du
Ben F. Luisi
Steven J. Ludtke
Zhao Wang
author_sort Xiaodong Shi
title In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
title_short In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
title_full In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
title_fullStr In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
title_full_unstemmed In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
title_sort in situ structure and assembly of the multidrug efflux pump acrab-tolc
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/28c29f6371ef4ce0931bd60ea29799b1
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