Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.

Tumor cell extravasation into the brain requires passage through the blood-brain barrier (BBB). There is evidence that exercise can alter the oxidation status of the brain microvasculature and protect against tumor cell invasion into the brain, although the mechanisms are not well understood. In the...

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Auteurs principaux: Gretchen Wolff, Jordan E Balke, Ibolya E Andras, Minseon Park, Michal Toborek
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
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Accès en ligne:https://doaj.org/article/28c48251c8f74cf09c3158c35c61c1dd
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