Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry

Abstract Plasmonic gold nanorods (GNRs) are finding increasing use in biomedicine due to their unique electromagnetic properties, optical contrast enhancement and biocompatibility; they also show promise as polarization contrast agents. However, quantification of their polarization-enhancing propert...

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Autores principales:	Subir Kumar Ray, Nirmalya Ghosh, Alex Vitkin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28c61f631068485baadfc2f610a4d8c5
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spelling	oai:doaj.org-article:28c61f631068485baadfc2f610a4d8c52021-12-02T19:16:15ZDiattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry10.1038/s41598-021-99430-62045-2322https://doaj.org/article/28c61f631068485baadfc2f610a4d8c52021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99430-6https://doaj.org/toc/2045-2322Abstract Plasmonic gold nanorods (GNRs) are finding increasing use in biomedicine due to their unique electromagnetic properties, optical contrast enhancement and biocompatibility; they also show promise as polarization contrast agents. However, quantification of their polarization-enhancing properties within heterogeneous turbid media remains challenging. We report on polarization response in controlled tissue phantoms consisting of dielectric microsphere scatterers with varying admixtures of GRNs. Experimental Mueller matrix measurements and polarization sensitive Monte-Carlo simulations show excellent agreement. Despite the GNRs’ 3D random orientation and distribution in the strong multiply scattering background, significant linear diattenuation and retardance were observed. These exclusive measurable characteristics of GNRs suggest their potential uses as contrast enhancers for polarimetric assessment of turbid biological tissue.Subir Kumar RayNirmalya GhoshAlex VitkinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Subir Kumar Ray Nirmalya Ghosh Alex Vitkin Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry
description	Abstract Plasmonic gold nanorods (GNRs) are finding increasing use in biomedicine due to their unique electromagnetic properties, optical contrast enhancement and biocompatibility; they also show promise as polarization contrast agents. However, quantification of their polarization-enhancing properties within heterogeneous turbid media remains challenging. We report on polarization response in controlled tissue phantoms consisting of dielectric microsphere scatterers with varying admixtures of GRNs. Experimental Mueller matrix measurements and polarization sensitive Monte-Carlo simulations show excellent agreement. Despite the GNRs’ 3D random orientation and distribution in the strong multiply scattering background, significant linear diattenuation and retardance were observed. These exclusive measurable characteristics of GNRs suggest their potential uses as contrast enhancers for polarimetric assessment of turbid biological tissue.
format	article
author	Subir Kumar Ray Nirmalya Ghosh Alex Vitkin
author_facet	Subir Kumar Ray Nirmalya Ghosh Alex Vitkin
author_sort	Subir Kumar Ray
title	Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry
title_short	Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry
title_full	Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry
title_fullStr	Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry
title_full_unstemmed	Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry
title_sort	diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by mueller matrix polarimetry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28c61f631068485baadfc2f610a4d8c5
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Diattenuation and retardance signature of plasmonic gold nanorods in turbid media revealed by Mueller matrix polarimetry

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