Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors
Brain tumors are particularly aggressive and represent a significant cause of morbidity and mortality in adults and children, affecting the global population and being responsible for 2.6% of all cancer deaths (as well as 30% of those in children and 20% in young adults). The blood-brain barrier (BB...
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MDPI AG
2021
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oai:doaj.org-article:28c78dabb43e4319886b33bba847ccfe2021-11-11T17:13:58ZCarbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors10.3390/ijms2221117831422-00671661-6596https://doaj.org/article/28c78dabb43e4319886b33bba847ccfe2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11783https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Brain tumors are particularly aggressive and represent a significant cause of morbidity and mortality in adults and children, affecting the global population and being responsible for 2.6% of all cancer deaths (as well as 30% of those in children and 20% in young adults). The blood-brain barrier (BBB) excludes almost 100% of the drugs targeting brain neoplasms, representing one of the most significant challenges to current brain cancer therapy. In the last decades, carbon dots have increasingly played the role of drug delivery systems with theranostic applications against cancer, thanks to their bright photoluminescence, solubility in bodily fluids, chemical stability, and biocompatibility. After a summary outlining brain tumors and the current drug delivery strategies devised in their therapeutic management, this review explores the most recent literature about the advances and open challenges in the employment of carbon dots as both diagnostic and therapeutic agents in the treatment of brain cancers, together with the strategies devised to allow them to cross the BBB effectively.Giovanna CalabreseGiovanna De LucaGiuseppe NocitoMaria Giovanna RizzoSofia Paola LombardoGiulia ChisariStefano ForteEmanuele Luigi SciutoSabrina ConociMDPI AGarticlebrain tumorsdrug-delivery systemsblood-brain barriernanoparticlescarbon dotsnanocarriersBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11783, p 11783 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
brain tumors drug-delivery systems blood-brain barrier nanoparticles carbon dots nanocarriers Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
brain tumors drug-delivery systems blood-brain barrier nanoparticles carbon dots nanocarriers Biology (General) QH301-705.5 Chemistry QD1-999 Giovanna Calabrese Giovanna De Luca Giuseppe Nocito Maria Giovanna Rizzo Sofia Paola Lombardo Giulia Chisari Stefano Forte Emanuele Luigi Sciuto Sabrina Conoci Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors |
| description |
Brain tumors are particularly aggressive and represent a significant cause of morbidity and mortality in adults and children, affecting the global population and being responsible for 2.6% of all cancer deaths (as well as 30% of those in children and 20% in young adults). The blood-brain barrier (BBB) excludes almost 100% of the drugs targeting brain neoplasms, representing one of the most significant challenges to current brain cancer therapy. In the last decades, carbon dots have increasingly played the role of drug delivery systems with theranostic applications against cancer, thanks to their bright photoluminescence, solubility in bodily fluids, chemical stability, and biocompatibility. After a summary outlining brain tumors and the current drug delivery strategies devised in their therapeutic management, this review explores the most recent literature about the advances and open challenges in the employment of carbon dots as both diagnostic and therapeutic agents in the treatment of brain cancers, together with the strategies devised to allow them to cross the BBB effectively. |
| format |
article |
| author |
Giovanna Calabrese Giovanna De Luca Giuseppe Nocito Maria Giovanna Rizzo Sofia Paola Lombardo Giulia Chisari Stefano Forte Emanuele Luigi Sciuto Sabrina Conoci |
| author_facet |
Giovanna Calabrese Giovanna De Luca Giuseppe Nocito Maria Giovanna Rizzo Sofia Paola Lombardo Giulia Chisari Stefano Forte Emanuele Luigi Sciuto Sabrina Conoci |
| author_sort |
Giovanna Calabrese |
| title |
Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors |
| title_short |
Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors |
| title_full |
Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors |
| title_fullStr |
Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors |
| title_full_unstemmed |
Carbon Dots: An Innovative Tool for Drug Delivery in Brain Tumors |
| title_sort |
carbon dots: an innovative tool for drug delivery in brain tumors |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/28c78dabb43e4319886b33bba847ccfe |
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