Alternative Splicing in Apicomplexan Parasites

ABSTRACT Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are essential for parasite growth. Recent ap...

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Autores principales:	Lee M. Yeoh, V. Vern Lee, Geoffrey I. McFadden, Stuart A. Ralph
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Plasmodium RNA splicing Toxoplasma apicomplexan parasites posttranscriptional control mechanisms Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/28c7a08d9aff4f279c385ed4b8eec46d
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spelling	oai:doaj.org-article:28c7a08d9aff4f279c385ed4b8eec46d2021-11-15T15:55:14ZAlternative Splicing in Apicomplexan Parasites10.1128/mBio.02866-182150-7511https://doaj.org/article/28c7a08d9aff4f279c385ed4b8eec46d2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02866-18https://doaj.org/toc/2150-7511ABSTRACT Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are essential for parasite growth. Recent approaches are now providing more wide-ranging surveys of the extent of alternative splicing; some indicate that alternative splicing is less widespread than in other model eukaryotes, whereas others suggest levels comparable to those of previously studied groups. In many cases, apicomplexan alternative splicing events appear not to generate multiple alternative proteins but instead produce aberrant or noncoding transcripts. Nonetheless, appropriate regulation of alternative splicing is clearly essential in Plasmodium and Toxoplasma parasites, suggesting a biological role for at least some of the alternative splicing observed. Several studies have now disrupted conserved regulators of alternative splicing and demonstrated lethal effects in apicomplexans. This minireview discusses methods to accurately determine the extent of alternative splicing in Apicomplexa and discuss potential biological roles for this conserved process in a phylum of parasites with compact genomes.Lee M. YeohV. Vern LeeGeoffrey I. McFaddenStuart A. RalphAmerican Society for MicrobiologyarticlePlasmodiumRNA splicingToxoplasmaapicomplexan parasitesposttranscriptional control mechanismsMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Plasmodium RNA splicing Toxoplasma apicomplexan parasites posttranscriptional control mechanisms Microbiology QR1-502
spellingShingle	Plasmodium RNA splicing Toxoplasma apicomplexan parasites posttranscriptional control mechanisms Microbiology QR1-502 Lee M. Yeoh V. Vern Lee Geoffrey I. McFadden Stuart A. Ralph Alternative Splicing in Apicomplexan Parasites
description	ABSTRACT Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are essential for parasite growth. Recent approaches are now providing more wide-ranging surveys of the extent of alternative splicing; some indicate that alternative splicing is less widespread than in other model eukaryotes, whereas others suggest levels comparable to those of previously studied groups. In many cases, apicomplexan alternative splicing events appear not to generate multiple alternative proteins but instead produce aberrant or noncoding transcripts. Nonetheless, appropriate regulation of alternative splicing is clearly essential in Plasmodium and Toxoplasma parasites, suggesting a biological role for at least some of the alternative splicing observed. Several studies have now disrupted conserved regulators of alternative splicing and demonstrated lethal effects in apicomplexans. This minireview discusses methods to accurately determine the extent of alternative splicing in Apicomplexa and discuss potential biological roles for this conserved process in a phylum of parasites with compact genomes.
format	article
author	Lee M. Yeoh V. Vern Lee Geoffrey I. McFadden Stuart A. Ralph
author_facet	Lee M. Yeoh V. Vern Lee Geoffrey I. McFadden Stuart A. Ralph
author_sort	Lee M. Yeoh
title	Alternative Splicing in Apicomplexan Parasites
title_short	Alternative Splicing in Apicomplexan Parasites
title_full	Alternative Splicing in Apicomplexan Parasites
title_fullStr	Alternative Splicing in Apicomplexan Parasites
title_full_unstemmed	Alternative Splicing in Apicomplexan Parasites
title_sort	alternative splicing in apicomplexan parasites
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/28c7a08d9aff4f279c385ed4b8eec46d
work_keys_str_mv	AT leemyeoh alternativesplicinginapicomplexanparasites AT vvernlee alternativesplicinginapicomplexanparasites AT geoffreyimcfadden alternativesplicinginapicomplexanparasites AT stuartaralph alternativesplicinginapicomplexanparasites
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Alternative Splicing in Apicomplexan Parasites

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