Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide

Abstract Self-nanoemulsifying drug delivery systems (SNEDDS) were used to enhance the dissolution rate of furosemide as a model for class IV drugs and the system was solidified into liquisolid tablets. SNEDDS of furosemide contained 10% Castor oil, 60% Cremophor EL, and 30% PEG 400. The mean droplet...

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Autores principales:	Lena Dalal, Abdul Wahab Allaf, Hind El-Zein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28cc1b7a797541f59747f4722db59a62
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spelling	oai:doaj.org-article:28cc1b7a797541f59747f4722db59a622021-12-02T14:12:08ZFormulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide10.1038/s41598-020-79940-52045-2322https://doaj.org/article/28cc1b7a797541f59747f4722db59a622021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79940-5https://doaj.org/toc/2045-2322Abstract Self-nanoemulsifying drug delivery systems (SNEDDS) were used to enhance the dissolution rate of furosemide as a model for class IV drugs and the system was solidified into liquisolid tablets. SNEDDS of furosemide contained 10% Castor oil, 60% Cremophor EL, and 30% PEG 400. The mean droplets size was 17.9 ± 4.5 nm. The theoretical model was used to calculate the amounts of the carrier (Avicel PH101) and coating materials (Aerosil 200) to prepare liquisolid powder. Carrier/coating materials ratio of 5/1 was used and Ludipress was added to the solid system, thus tablets with hardness of 45 ± 2 N were obtained. Liquisolid tablets showed 2-folds increase in drug release as compared to the generic tablets after 60 min in HCl 0.1 N using USP apparatus-II. Furosemide loaded SNEDDS tablets have great prospects for further in vivo studies, and the theoretical model is useful for calculating the adequate amounts of adsorbents required to solidify these systems.Lena DalalAbdul Wahab AllafHind El-ZeinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lena Dalal Abdul Wahab Allaf Hind El-Zein Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
description	Abstract Self-nanoemulsifying drug delivery systems (SNEDDS) were used to enhance the dissolution rate of furosemide as a model for class IV drugs and the system was solidified into liquisolid tablets. SNEDDS of furosemide contained 10% Castor oil, 60% Cremophor EL, and 30% PEG 400. The mean droplets size was 17.9 ± 4.5 nm. The theoretical model was used to calculate the amounts of the carrier (Avicel PH101) and coating materials (Aerosil 200) to prepare liquisolid powder. Carrier/coating materials ratio of 5/1 was used and Ludipress was added to the solid system, thus tablets with hardness of 45 ± 2 N were obtained. Liquisolid tablets showed 2-folds increase in drug release as compared to the generic tablets after 60 min in HCl 0.1 N using USP apparatus-II. Furosemide loaded SNEDDS tablets have great prospects for further in vivo studies, and the theoretical model is useful for calculating the adequate amounts of adsorbents required to solidify these systems.
format	article
author	Lena Dalal Abdul Wahab Allaf Hind El-Zein
author_facet	Lena Dalal Abdul Wahab Allaf Hind El-Zein
author_sort	Lena Dalal
title	Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
title_short	Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
title_full	Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
title_fullStr	Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
title_full_unstemmed	Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
title_sort	formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28cc1b7a797541f59747f4722db59a62
work_keys_str_mv	AT lenadalal formulationandinvitroevaluationofselfnanoemulsifyingliquisolidtabletsoffurosemide AT abdulwahaballaf formulationandinvitroevaluationofselfnanoemulsifyingliquisolidtabletsoffurosemide AT hindelzein formulationandinvitroevaluationofselfnanoemulsifyingliquisolidtabletsoffurosemide
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Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide

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