Topoisomerase-Mediated DNA Damage in Neurological Disorders

The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant to the development of neuronal dysfunction are poo...

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Autores principales:	Morgan Crewe, Ram Madabhushi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	topoisomerase DNA cleavage complexes TDP1 TDP2 neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/28d051b1724940e0bb7fe3239781cf3d
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spelling	oai:doaj.org-article:28d051b1724940e0bb7fe3239781cf3d2021-12-01T02:11:18ZTopoisomerase-Mediated DNA Damage in Neurological Disorders1663-436510.3389/fnagi.2021.751742https://doaj.org/article/28d051b1724940e0bb7fe3239781cf3d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.751742/fullhttps://doaj.org/toc/1663-4365The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant to the development of neuronal dysfunction are poorly understood. The identification of primarily neurological abnormalities in patients with mutations in TDP1 and TDP2 suggest that topoisomerase-mediated DNA damage could be an important underlying source of neuronal dysfunction. Here we review the potential sources of topoisomerase-induced DNA damage in neurons, describe the cellular mechanisms that have evolved to repair such damage, and discuss the importance of these repair mechanisms for preventing neurological disorders.Morgan CreweRam MadabhushiFrontiers Media S.A.articletopoisomeraseDNA cleavage complexesTDP1TDP2neurodegenerationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	topoisomerase DNA cleavage complexes TDP1 TDP2 neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	topoisomerase DNA cleavage complexes TDP1 TDP2 neurodegeneration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Morgan Crewe Ram Madabhushi Topoisomerase-Mediated DNA Damage in Neurological Disorders
description	The nervous system is vulnerable to genomic instability and mutations in DNA damage response factors lead to numerous developmental and progressive neurological disorders. Despite this, the sources and mechanisms of DNA damage that are most relevant to the development of neuronal dysfunction are poorly understood. The identification of primarily neurological abnormalities in patients with mutations in TDP1 and TDP2 suggest that topoisomerase-mediated DNA damage could be an important underlying source of neuronal dysfunction. Here we review the potential sources of topoisomerase-induced DNA damage in neurons, describe the cellular mechanisms that have evolved to repair such damage, and discuss the importance of these repair mechanisms for preventing neurological disorders.
format	article
author	Morgan Crewe Ram Madabhushi
author_facet	Morgan Crewe Ram Madabhushi
author_sort	Morgan Crewe
title	Topoisomerase-Mediated DNA Damage in Neurological Disorders
title_short	Topoisomerase-Mediated DNA Damage in Neurological Disorders
title_full	Topoisomerase-Mediated DNA Damage in Neurological Disorders
title_fullStr	Topoisomerase-Mediated DNA Damage in Neurological Disorders
title_full_unstemmed	Topoisomerase-Mediated DNA Damage in Neurological Disorders
title_sort	topoisomerase-mediated dna damage in neurological disorders
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/28d051b1724940e0bb7fe3239781cf3d
work_keys_str_mv	AT morgancrewe topoisomerasemediateddnadamageinneurologicaldisorders AT rammadabhushi topoisomerasemediateddnadamageinneurologicaldisorders
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Topoisomerase-Mediated DNA Damage in Neurological Disorders

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