The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis
Purpose: To evaluate therapeutic effectiveness of antibacterial triclosan (TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-induced experimental periodontitis in rats. Methodology: A total of 72 Sprague–Dawley rats were used in this study. Four groups (n = 18 each) we...
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Elsevier
2021
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oai:doaj.org-article:28d1dbe3af154cf09db0c4335b7e97692021-11-10T04:19:32ZThe evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis1013-905210.1016/j.sdentj.2020.08.008https://doaj.org/article/28d1dbe3af154cf09db0c4335b7e97692021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1013905220307677https://doaj.org/toc/1013-9052Purpose: To evaluate therapeutic effectiveness of antibacterial triclosan (TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-induced experimental periodontitis in rats. Methodology: A total of 72 Sprague–Dawley rats were used in this study. Four groups (n = 18 each) were randomly created: Group 1 – neither subjected to experimental periodontitis nor to any treatment; Group 2 – subjected to experimental periodontitis but not treated; Group 3 – subjected to experimental periodontitis and then treated with the developed nanogels; Group 4 – subjected to experimental periodontitis and then placed on a mixture of pure TCS and FLB treatment. The experimental periodontitis was induced on the lower incisors by applying a ligature which was kept for 14 days. Treatment was done for 7 days, and sampling was done at 7, 14, and 28 day of the post-induction experimental period. Morphometric analysis was conducted to assess the clinical outcomes and healing effect. Results: The morphometric findings showed that the group treated with the developed TCS and FLB-loaded nanogels recovered better and faster than a mixture of pure TCS and FLB. At 28 day of the experimental period, there was no significant difference (p > 0.05) between the baseline control group and the nanogels treated group. Conclusions: The developed TCS and FLB-loaded nanogels was found to be effective in the treatment of experimental periodontitis in rats. The used experimental periodontitis model was found to be simple and easily reproducible.Nafiu AminuMun-Fei YamSiok-Yee ChanIdris BelloNura Muhammad UmarTanko NuhuSeok-Ming TohElsevierarticleExperimental periodontitisMorphometric analysisRat incisorsNanogelsTriclosanFlurbiprofenMedicineRDentistryRK1-715ENSaudi Dental Journal, Vol 33, Iss 7, Pp 554-559 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Experimental periodontitis Morphometric analysis Rat incisors Nanogels Triclosan Flurbiprofen Medicine R Dentistry RK1-715 |
| spellingShingle |
Experimental periodontitis Morphometric analysis Rat incisors Nanogels Triclosan Flurbiprofen Medicine R Dentistry RK1-715 Nafiu Aminu Mun-Fei Yam Siok-Yee Chan Idris Bello Nura Muhammad Umar Tanko Nuhu Seok-Ming Toh The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| description |
Purpose: To evaluate therapeutic effectiveness of antibacterial triclosan (TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-induced experimental periodontitis in rats. Methodology: A total of 72 Sprague–Dawley rats were used in this study. Four groups (n = 18 each) were randomly created: Group 1 – neither subjected to experimental periodontitis nor to any treatment; Group 2 – subjected to experimental periodontitis but not treated; Group 3 – subjected to experimental periodontitis and then treated with the developed nanogels; Group 4 – subjected to experimental periodontitis and then placed on a mixture of pure TCS and FLB treatment. The experimental periodontitis was induced on the lower incisors by applying a ligature which was kept for 14 days. Treatment was done for 7 days, and sampling was done at 7, 14, and 28 day of the post-induction experimental period. Morphometric analysis was conducted to assess the clinical outcomes and healing effect. Results: The morphometric findings showed that the group treated with the developed TCS and FLB-loaded nanogels recovered better and faster than a mixture of pure TCS and FLB. At 28 day of the experimental period, there was no significant difference (p > 0.05) between the baseline control group and the nanogels treated group. Conclusions: The developed TCS and FLB-loaded nanogels was found to be effective in the treatment of experimental periodontitis in rats. The used experimental periodontitis model was found to be simple and easily reproducible. |
| format |
article |
| author |
Nafiu Aminu Mun-Fei Yam Siok-Yee Chan Idris Bello Nura Muhammad Umar Tanko Nuhu Seok-Ming Toh |
| author_facet |
Nafiu Aminu Mun-Fei Yam Siok-Yee Chan Idris Bello Nura Muhammad Umar Tanko Nuhu Seok-Ming Toh |
| author_sort |
Nafiu Aminu |
| title |
The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| title_short |
The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| title_full |
The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| title_fullStr |
The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| title_full_unstemmed |
The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| title_sort |
evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/28d1dbe3af154cf09db0c4335b7e9769 |
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