Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with n...

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Autores principales:	Xiao-Ping Liu, Karl R. Koehler, Andrew M. Mikosz, Eri Hashino, Jeffrey R. Holt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28d1e711fb1b4e9e9e08b5c469b3d2a3
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spelling	oai:doaj.org-article:28d1e711fb1b4e9e9e08b5c469b3d2a32021-12-02T14:40:15ZFunctional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells10.1038/ncomms115082041-1723https://doaj.org/article/28d1e711fb1b4e9e9e08b5c469b3d2a32016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11508https://doaj.org/toc/2041-1723Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with neurons.Xiao-Ping LiuKarl R. KoehlerAndrew M. MikoszEri HashinoJeffrey R. HoltNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao-Ping Liu Karl R. Koehler Andrew M. Mikosz Eri Hashino Jeffrey R. Holt Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
description	Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with neurons.
format	article
author	Xiao-Ping Liu Karl R. Koehler Andrew M. Mikosz Eri Hashino Jeffrey R. Holt
author_facet	Xiao-Ping Liu Karl R. Koehler Andrew M. Mikosz Eri Hashino Jeffrey R. Holt
author_sort	Xiao-Ping Liu
title	Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_short	Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_full	Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_fullStr	Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_full_unstemmed	Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_sort	functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/28d1e711fb1b4e9e9e08b5c469b3d2a3
work_keys_str_mv	AT xiaopingliu functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells AT karlrkoehler functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells AT andrewmmikosz functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells AT erihashino functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells AT jeffreyrholt functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells
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Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

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