Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with n...

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Main Authors: Xiao-Ping Liu, Karl R. Koehler, Andrew M. Mikosz, Eri Hashino, Jeffrey R. Holt
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/28d1e711fb1b4e9e9e08b5c469b3d2a3
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spelling oai:doaj.org-article:28d1e711fb1b4e9e9e08b5c469b3d2a32021-12-02T14:40:15ZFunctional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells10.1038/ncomms115082041-1723https://doaj.org/article/28d1e711fb1b4e9e9e08b5c469b3d2a32016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11508https://doaj.org/toc/2041-1723Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with neurons.Xiao-Ping LiuKarl R. KoehlerAndrew M. MikoszEri HashinoJeffrey R. HoltNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiao-Ping Liu
Karl R. Koehler
Andrew M. Mikosz
Eri Hashino
Jeffrey R. Holt
Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
description Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with neurons.
format article
author Xiao-Ping Liu
Karl R. Koehler
Andrew M. Mikosz
Eri Hashino
Jeffrey R. Holt
author_facet Xiao-Ping Liu
Karl R. Koehler
Andrew M. Mikosz
Eri Hashino
Jeffrey R. Holt
author_sort Xiao-Ping Liu
title Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_short Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_full Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_fullStr Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_full_unstemmed Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
title_sort functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/28d1e711fb1b4e9e9e08b5c469b3d2a3
work_keys_str_mv AT xiaopingliu functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells
AT karlrkoehler functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells
AT andrewmmikosz functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells
AT erihashino functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells
AT jeffreyrholt functionaldevelopmentofmechanosensitivehaircellsinstemcellderivedorganoidsparallelsnativevestibularhaircells
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