Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice

Robert Jacobs, Mostafa Aboouf, et al. examined the effect of erythropoietin (EPO) in hippocampal mitochondrial function and memory in two mouse models: one overexpressing EPO in the brain, and juvenile mice treated during three days with a high dose of intraperitoneal EPO. Their results suggest that...

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Autores principales: Robert A. Jacobs, Mostafa A. Aboouf, Christina Koester-Hegmann, Paola Muttathukunnel, Sofien Laouafa, Christian Arias-Reyes, Markus Thiersch, Jorge Soliz, Max Gassmann, Edith M. Schneider Gasser
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/28d43af59b814496ad5a6dc3b560f703
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Sumario:Robert Jacobs, Mostafa Aboouf, et al. examined the effect of erythropoietin (EPO) in hippocampal mitochondrial function and memory in two mouse models: one overexpressing EPO in the brain, and juvenile mice treated during three days with a high dose of intraperitoneal EPO. Their results suggest that erythropoietin in the neonatal brain may impact spatial memory by increasing mitochondrial content.