A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding
Abstract Antibody treatment is currently the only available countermeasure for botulism, a fatal illness caused by flaccid paralysis of muscles due to botulinum neurotoxin (BoNT) intoxication. Among the seven major serotypes of BoNT/A-G, BoNT/A poses the most serious threat to humans because of its...
Enregistré dans:
Auteurs principaux: | Guorui Yao, Kwok-ho Lam, Jasmin Weisemann, Lisheng Peng, Nadja Krez, Kay Perry, Charles B. Shoemaker, Min Dong, Andreas Rummel, Rongsheng Jin |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/28d488b3904246b2b17c6304fa26a9f6 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1
par: Kwok-ho Lam, et autres
Publié: (2018) -
Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin
par: Nai-Jia Huang, et autres
Publié: (2017) -
On Botulinum Neurotoxin Variability
par: Cesare Montecucco, et autres
Publié: (2015) -
Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain.
par: Axel T Brunger, et autres
Publié: (2007) -
Characterization of immune response induced against catalytic domain of botulinum neurotoxin type E
par: Priyanka Sonkar, et autres
Publié: (2020)