A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding

Abstract Antibody treatment is currently the only available countermeasure for botulism, a fatal illness caused by flaccid paralysis of muscles due to botulinum neurotoxin (BoNT) intoxication. Among the seven major serotypes of BoNT/A-G, BoNT/A poses the most serious threat to humans because of its...

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Auteurs principaux: Guorui Yao, Kwok-ho Lam, Jasmin Weisemann, Lisheng Peng, Nadja Krez, Kay Perry, Charles B. Shoemaker, Min Dong, Andreas Rummel, Rongsheng Jin
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/28d488b3904246b2b17c6304fa26a9f6
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