Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria

Abstract Cooperation is fundamental to the survival of many bacterial species. Previous studies have shown that spatial structure can both promote and suppress cooperation. Most environments where bacteria are found are periodically disturbed, which can affect the spatial structure of the population...

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Autores principales:	Cortney E. Wilson, Allison J. Lopatkin, Travis J. A. Craddock, William W. Driscoll, Omar Tonsi Eldakar, Jose V. Lopez, Robert P. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28d84355e3cc41708817afdabb42b3b4
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spelling	oai:doaj.org-article:28d84355e3cc41708817afdabb42b3b42021-12-02T12:31:53ZCooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria10.1038/s41598-017-00588-92045-2322https://doaj.org/article/28d84355e3cc41708817afdabb42b3b42017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00588-9https://doaj.org/toc/2045-2322Abstract Cooperation is fundamental to the survival of many bacterial species. Previous studies have shown that spatial structure can both promote and suppress cooperation. Most environments where bacteria are found are periodically disturbed, which can affect the spatial structure of the population. Despite the important role that spatial disturbances play in maintaining ecological relationships, it remains unclear as to how periodic spatial disturbances affect bacteria dependent on cooperation for survival. Here, we use bacteria engineered with a strong Allee effect to investigate how the frequency of periodic spatial disturbances affects cooperation. We show that at intermediate frequencies of spatial disturbance, the ability of the bacterial population to cooperate is perturbed. A mathematical model demonstrates that periodic spatial disturbance leads to a tradeoff between accessing an autoinducer and accessing nutrients, which determines the ability of the bacteria to cooperate. Based on this relationship, we alter the ability of the bacteria to access an autoinducer. We show that increased access to an autoinducer can enhance cooperation, but can also reduce ecological resistance, defined as the ability of a population to resist changes due to disturbance. Our results may have implications in maintaining stability of microbial communities and in the treatment of infectious diseases.Cortney E. WilsonAllison J. LopatkinTravis J. A. CraddockWilliam W. DriscollOmar Tonsi EldakarJose V. LopezRobert P. SmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cortney E. Wilson Allison J. Lopatkin Travis J. A. Craddock William W. Driscoll Omar Tonsi Eldakar Jose V. Lopez Robert P. Smith Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
description	Abstract Cooperation is fundamental to the survival of many bacterial species. Previous studies have shown that spatial structure can both promote and suppress cooperation. Most environments where bacteria are found are periodically disturbed, which can affect the spatial structure of the population. Despite the important role that spatial disturbances play in maintaining ecological relationships, it remains unclear as to how periodic spatial disturbances affect bacteria dependent on cooperation for survival. Here, we use bacteria engineered with a strong Allee effect to investigate how the frequency of periodic spatial disturbances affects cooperation. We show that at intermediate frequencies of spatial disturbance, the ability of the bacterial population to cooperate is perturbed. A mathematical model demonstrates that periodic spatial disturbance leads to a tradeoff between accessing an autoinducer and accessing nutrients, which determines the ability of the bacteria to cooperate. Based on this relationship, we alter the ability of the bacteria to access an autoinducer. We show that increased access to an autoinducer can enhance cooperation, but can also reduce ecological resistance, defined as the ability of a population to resist changes due to disturbance. Our results may have implications in maintaining stability of microbial communities and in the treatment of infectious diseases.
format	article
author	Cortney E. Wilson Allison J. Lopatkin Travis J. A. Craddock William W. Driscoll Omar Tonsi Eldakar Jose V. Lopez Robert P. Smith
author_facet	Cortney E. Wilson Allison J. Lopatkin Travis J. A. Craddock William W. Driscoll Omar Tonsi Eldakar Jose V. Lopez Robert P. Smith
author_sort	Cortney E. Wilson
title	Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
title_short	Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
title_full	Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
title_fullStr	Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
title_full_unstemmed	Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
title_sort	cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/28d84355e3cc41708817afdabb42b3b4
work_keys_str_mv	AT cortneyewilson cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria AT allisonjlopatkin cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria AT travisjacraddock cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria AT williamwdriscoll cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria AT omartonsieldakar cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria AT josevlopez cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria AT robertpsmith cooperationandcompetitionshapeecologicalresistanceduringperiodicspatialdisturbanceofengineeredbacteria
_version_	1718394206033018880

Cooperation and competition shape ecological resistance during periodic spatial disturbance of engineered bacteria

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