Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin

Koji Sugioka1, Masahiko Fukuda1, Shohei Komoto1, Motoki Itahashi1, Masakazu Yamada2, Yoshikazu Shimomura11Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama City, Osaka, Japan; 2Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Cen...

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Autores principales:	Koji Sugioka, Masahiko Fukuda, Shohei Komoto, Motoki Itahashi, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/28d937216a2941babe7d41a93076f7e5
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spelling	oai:doaj.org-article:28d937216a2941babe7d41a93076f7e52021-12-02T01:24:27ZIntraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin1177-54671177-5483https://doaj.org/article/28d937216a2941babe7d41a93076f7e52009-10-01T00:00:00Zhttp://www.dovepress.com/intraocular-penetration-of-sequentially-instilled-topical-moxifloxacin-a3628https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Koji Sugioka1, Masahiko Fukuda1, Shohei Komoto1, Motoki Itahashi1, Masakazu Yamada2, Yoshikazu Shimomura11Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama City, Osaka, Japan; 2Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, JapanPurpose: The objective of the study was to compare the intraocular penetration levels of the newer fluoroquinolones, moxifloxacin, gatifloxacin, and levofloxacin in the rabbit&rsquo;s cornea, aqueous humor, and conjunctiva after topical instillation.Methods: 0.5% moxifloxacin, 0.3% gatifloxacin, and 0.5% levofloxacin were instilled in random sequence in both eyes of nine New Zealand White rabbits at two-minute intervals. Instillation was repeated every 15 minutes for a total of three drops of each fluoroquinolone per eye. Three additional animals had only moxifloxacin instilled bilaterally using the same schedule. Sixty minutes after the final instillation, the rabbits were sacrificed for determination of corneal, aqueous humor, and conjunctival fluoroquinolone concentrations using highperformance liquid chromatography.Results: Moxifloxacin achieved significantly higher concentrations than levofloxacin and gatifloxacin in the cornea (P = 0.0102 and P = 0.0006, respectively), aqueous humor (P = 0.0015 and P &lt; 0.0001, respectively), and conjunctiva (P = 0.0191 and P = 0.0236, respectively). Conclusions: 0.5% moxifloxacin eyedrops provided superior intraocular penetration in rabbits&rsquo;&nbsp;eyes compared with the two other fluoroquinolones, 0.5% levofloxacin and 0.3% gatifloxacin.Keywords: fluoroquinolone, gatifloxacin, levofloxacin, moxifloxacin, penetration, rabbit Koji SugiokaMasahiko FukudaShohei KomotoMotoki Itahashiet al.Dove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 553-557 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Koji Sugioka Masahiko Fukuda Shohei Komoto Motoki Itahashi et al. Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
description	Koji Sugioka1, Masahiko Fukuda1, Shohei Komoto1, Motoki Itahashi1, Masakazu Yamada2, Yoshikazu Shimomura11Department of Ophthalmology, Kinki University School of Medicine, Osaka-Sayama City, Osaka, Japan; 2Division for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, JapanPurpose: The objective of the study was to compare the intraocular penetration levels of the newer fluoroquinolones, moxifloxacin, gatifloxacin, and levofloxacin in the rabbit&rsquo;s cornea, aqueous humor, and conjunctiva after topical instillation.Methods: 0.5% moxifloxacin, 0.3% gatifloxacin, and 0.5% levofloxacin were instilled in random sequence in both eyes of nine New Zealand White rabbits at two-minute intervals. Instillation was repeated every 15 minutes for a total of three drops of each fluoroquinolone per eye. Three additional animals had only moxifloxacin instilled bilaterally using the same schedule. Sixty minutes after the final instillation, the rabbits were sacrificed for determination of corneal, aqueous humor, and conjunctival fluoroquinolone concentrations using highperformance liquid chromatography.Results: Moxifloxacin achieved significantly higher concentrations than levofloxacin and gatifloxacin in the cornea (P = 0.0102 and P = 0.0006, respectively), aqueous humor (P = 0.0015 and P &lt; 0.0001, respectively), and conjunctiva (P = 0.0191 and P = 0.0236, respectively). Conclusions: 0.5% moxifloxacin eyedrops provided superior intraocular penetration in rabbits&rsquo;&nbsp;eyes compared with the two other fluoroquinolones, 0.5% levofloxacin and 0.3% gatifloxacin.Keywords: fluoroquinolone, gatifloxacin, levofloxacin, moxifloxacin, penetration, rabbit
format	article
author	Koji Sugioka Masahiko Fukuda Shohei Komoto Motoki Itahashi et al.
author_facet	Koji Sugioka Masahiko Fukuda Shohei Komoto Motoki Itahashi et al.
author_sort	Koji Sugioka
title	Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
title_short	Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
title_full	Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
title_fullStr	Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
title_full_unstemmed	Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
title_sort	intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/28d937216a2941babe7d41a93076f7e5
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Intraocular penetration of sequentially instilled topical moxifloxacin, gatifloxacin, and levofloxacin

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