Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.

<h4>Background</h4>Low birth weight and high childhood body mass index (BMI) is each associated with an increased risk of coronary heart disease (CHD) in adult life. We studied individual and combined associations of birth weight and childhood BMI with the risk of CHD in adulthood.<h4...

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Autores principales:	Lise Geisler Andersen, Lars Angquist, Johan G Eriksson, Tom Forsen, Michael Gamborg, Clive Osmond, Jennifer L Baker, Thorkild I A Sørensen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/28d9fc73c70c4c43abf8b7dffa592634
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spelling	oai:doaj.org-article:28d9fc73c70c4c43abf8b7dffa5926342021-11-18T07:36:31ZBirth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.1932-620310.1371/journal.pone.0014126https://doaj.org/article/28d9fc73c70c4c43abf8b7dffa5926342010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21124730/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Low birth weight and high childhood body mass index (BMI) is each associated with an increased risk of coronary heart disease (CHD) in adult life. We studied individual and combined associations of birth weight and childhood BMI with the risk of CHD in adulthood.<h4>Methods/principal findings</h4>Birth weight and BMI at age seven years were available in 216,771 Danish and Finnish individuals born 1924-1976. Linkage to national registers for hospitalization and causes of death identified 8,805 CHD events during up to 33 years of follow-up (median = 24 years) after age 25 years. Analyses were conducted with Cox regression based on restricted cubic splines. Using median birth weight of 3.4 kg as reference, a non-linear relation between birth weight and CHD was found. It was not significantly different between cohorts, or between men and women, nor was the association altered by childhood BMI. For birth weights below 3.4 kg, the risk of CHD increased linearly and reached 1.28 (95% confidence limits: 1.13 to 1.44) at 2 kg. Above 3.4 kg the association weakened, and from about 4 kg there was virtually no association. BMI at age seven years was strongly positively associated with the risk of CHD and the relation was not altered by birth weight. The excess risk in individuals with a birth weight of 2.5 kg and a BMI of 17.7 kg/m(2) at age seven years was 44% (95% CI: 30% to 59%) compared with individuals with median values of birth weight (3.4 kg) and BMI (15.3 kg/m(2)).<h4>Conclusions/significance</h4>Birth weight and BMI at age seven years appeared independently associated with the risk of CHD in adulthood. From a public health perspective we suggest that particular attention should be paid to children with a birth weight below the average in combination with excess relative weight in childhood.Lise Geisler AndersenLars AngquistJohan G ErikssonTom ForsenMichael GamborgClive OsmondJennifer L BakerThorkild I A SørensenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e14126 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lise Geisler Andersen Lars Angquist Johan G Eriksson Tom Forsen Michael Gamborg Clive Osmond Jennifer L Baker Thorkild I A Sørensen Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
description	<h4>Background</h4>Low birth weight and high childhood body mass index (BMI) is each associated with an increased risk of coronary heart disease (CHD) in adult life. We studied individual and combined associations of birth weight and childhood BMI with the risk of CHD in adulthood.<h4>Methods/principal findings</h4>Birth weight and BMI at age seven years were available in 216,771 Danish and Finnish individuals born 1924-1976. Linkage to national registers for hospitalization and causes of death identified 8,805 CHD events during up to 33 years of follow-up (median = 24 years) after age 25 years. Analyses were conducted with Cox regression based on restricted cubic splines. Using median birth weight of 3.4 kg as reference, a non-linear relation between birth weight and CHD was found. It was not significantly different between cohorts, or between men and women, nor was the association altered by childhood BMI. For birth weights below 3.4 kg, the risk of CHD increased linearly and reached 1.28 (95% confidence limits: 1.13 to 1.44) at 2 kg. Above 3.4 kg the association weakened, and from about 4 kg there was virtually no association. BMI at age seven years was strongly positively associated with the risk of CHD and the relation was not altered by birth weight. The excess risk in individuals with a birth weight of 2.5 kg and a BMI of 17.7 kg/m(2) at age seven years was 44% (95% CI: 30% to 59%) compared with individuals with median values of birth weight (3.4 kg) and BMI (15.3 kg/m(2)).<h4>Conclusions/significance</h4>Birth weight and BMI at age seven years appeared independently associated with the risk of CHD in adulthood. From a public health perspective we suggest that particular attention should be paid to children with a birth weight below the average in combination with excess relative weight in childhood.
format	article
author	Lise Geisler Andersen Lars Angquist Johan G Eriksson Tom Forsen Michael Gamborg Clive Osmond Jennifer L Baker Thorkild I A Sørensen
author_facet	Lise Geisler Andersen Lars Angquist Johan G Eriksson Tom Forsen Michael Gamborg Clive Osmond Jennifer L Baker Thorkild I A Sørensen
author_sort	Lise Geisler Andersen
title	Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
title_short	Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
title_full	Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
title_fullStr	Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
title_full_unstemmed	Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
title_sort	birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/28d9fc73c70c4c43abf8b7dffa592634
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Birth weight, childhood body mass index and risk of coronary heart disease in adults: combined historical cohort studies.

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