DNA unwinding mechanism of a eukaryotic replicative CMG helicase

The DNA duplex is known to be split apart in a steric exclusion manner during replication, but the specific mechanism has remained unclear. Here the authors present a cryo-EM structure of a eukaryotic replicative CMG helicase on forked DNA, revealing the mechanism of DNA unwinding.

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Autores principales:	Zuanning Yuan, Roxana Georgescu, Lin Bai, Dan Zhang, Huilin Li, Michael E. O’Donnell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28dfe286574d4c29930ab9b725ad275e
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id	oai:doaj.org-article:28dfe286574d4c29930ab9b725ad275e
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spelling	oai:doaj.org-article:28dfe286574d4c29930ab9b725ad275e2021-12-02T16:56:50ZDNA unwinding mechanism of a eukaryotic replicative CMG helicase10.1038/s41467-020-14577-62041-1723https://doaj.org/article/28dfe286574d4c29930ab9b725ad275e2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14577-6https://doaj.org/toc/2041-1723The DNA duplex is known to be split apart in a steric exclusion manner during replication, but the specific mechanism has remained unclear. Here the authors present a cryo-EM structure of a eukaryotic replicative CMG helicase on forked DNA, revealing the mechanism of DNA unwinding.Zuanning YuanRoxana GeorgescuLin BaiDan ZhangHuilin LiMichael E. O’DonnellNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zuanning Yuan Roxana Georgescu Lin Bai Dan Zhang Huilin Li Michael E. O’Donnell DNA unwinding mechanism of a eukaryotic replicative CMG helicase
description	The DNA duplex is known to be split apart in a steric exclusion manner during replication, but the specific mechanism has remained unclear. Here the authors present a cryo-EM structure of a eukaryotic replicative CMG helicase on forked DNA, revealing the mechanism of DNA unwinding.
format	article
author	Zuanning Yuan Roxana Georgescu Lin Bai Dan Zhang Huilin Li Michael E. O’Donnell
author_facet	Zuanning Yuan Roxana Georgescu Lin Bai Dan Zhang Huilin Li Michael E. O’Donnell
author_sort	Zuanning Yuan
title	DNA unwinding mechanism of a eukaryotic replicative CMG helicase
title_short	DNA unwinding mechanism of a eukaryotic replicative CMG helicase
title_full	DNA unwinding mechanism of a eukaryotic replicative CMG helicase
title_fullStr	DNA unwinding mechanism of a eukaryotic replicative CMG helicase
title_full_unstemmed	DNA unwinding mechanism of a eukaryotic replicative CMG helicase
title_sort	dna unwinding mechanism of a eukaryotic replicative cmg helicase
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/28dfe286574d4c29930ab9b725ad275e
work_keys_str_mv	AT zuanningyuan dnaunwindingmechanismofaeukaryoticreplicativecmghelicase AT roxanageorgescu dnaunwindingmechanismofaeukaryoticreplicativecmghelicase AT linbai dnaunwindingmechanismofaeukaryoticreplicativecmghelicase AT danzhang dnaunwindingmechanismofaeukaryoticreplicativecmghelicase AT huilinli dnaunwindingmechanismofaeukaryoticreplicativecmghelicase AT michaeleodonnell dnaunwindingmechanismofaeukaryoticreplicativecmghelicase
_version_	1718382670171340800

DNA unwinding mechanism of a eukaryotic replicative CMG helicase

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