PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis

The polycomb repressive complex 2 (PRC2) is a histone methyltransferase regulating cell differentiation and identity. Here, the authors show that the vertebrate-specific PRC2 accessory subunit PALI1 facilitates substrate binding by the complex and elucidate the allosteric mechanism of PALI1- mediate...

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Autores principales:	Qi Zhang, Samuel C. Agius, Sarena F. Flanigan, Michael Uckelmann, Vitalina Levina, Brady M. Owen, Chen Davidovich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28e111a4e42249e7b0c766b5a9d29549
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spelling	oai:doaj.org-article:28e111a4e42249e7b0c766b5a9d295492021-12-02T16:14:24ZPALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis10.1038/s41467-021-24866-32041-1723https://doaj.org/article/28e111a4e42249e7b0c766b5a9d295492021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24866-3https://doaj.org/toc/2041-1723The polycomb repressive complex 2 (PRC2) is a histone methyltransferase regulating cell differentiation and identity. Here, the authors show that the vertebrate-specific PRC2 accessory subunit PALI1 facilitates substrate binding by the complex and elucidate the allosteric mechanism of PALI1- mediated PRC2 activation.Qi ZhangSamuel C. AgiusSarena F. FlaniganMichael UckelmannVitalina LevinaBrady M. OwenChen DavidovichNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Zhang Samuel C. Agius Sarena F. Flanigan Michael Uckelmann Vitalina Levina Brady M. Owen Chen Davidovich PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
description	The polycomb repressive complex 2 (PRC2) is a histone methyltransferase regulating cell differentiation and identity. Here, the authors show that the vertebrate-specific PRC2 accessory subunit PALI1 facilitates substrate binding by the complex and elucidate the allosteric mechanism of PALI1- mediated PRC2 activation.
format	article
author	Qi Zhang Samuel C. Agius Sarena F. Flanigan Michael Uckelmann Vitalina Levina Brady M. Owen Chen Davidovich
author_facet	Qi Zhang Samuel C. Agius Sarena F. Flanigan Michael Uckelmann Vitalina Levina Brady M. Owen Chen Davidovich
author_sort	Qi Zhang
title	PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
title_short	PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
title_full	PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
title_fullStr	PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
title_full_unstemmed	PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
title_sort	pali1 facilitates dna and nucleosome binding by prc2 and triggers an allosteric activation of catalysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/28e111a4e42249e7b0c766b5a9d29549
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_version_	1718384281531711488

PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis

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