Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1

Tomoko Ueda-Consolvo, Akio Miyakoshi, Hironori Ozaki, Satoshi Houki, Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose: To report a series of three cases of neurofibromatosis type 1 examined by near-infrare...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ueda-Consolvo T, Miyakoshi A, Ozaki H, Houki S, Hayashi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/28e35e034b4b454dafd94fb7e4bb7696
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:28e35e034b4b454dafd94fb7e4bb7696
record_format	dspace
spelling	oai:doaj.org-article:28e35e034b4b454dafd94fb7e4bb76962021-12-02T05:00:34ZNear-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 11177-54671177-5483https://doaj.org/article/28e35e034b4b454dafd94fb7e4bb76962012-07-01T00:00:00Zhttp://www.dovepress.com/near-infrared-fundus-autofluorescence-visualized-melanin-in-the-choroi-a10525https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Tomoko Ueda-Consolvo, Akio Miyakoshi, Hironori Ozaki, Satoshi Houki, Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose: To report a series of three cases of neurofibromatosis type 1 examined by near-infrared fundus autofluorescence (NIR-AF) with a scanning laser ophthalmoscope and spectral-domain optical coherence tomography (OCT) to show the characteristics of choroidal abnormalities.Methods: Retrospective case series. Six eyes of three patients were examined by conventional fundus examinations, near-infrared monochromatic light reflectance (NIR-R) and NIR-AF, OCT, fluorescein angiography, and indocyanine green angiography.Results: All eyes showed multiple bright patchy regions in the choroid of the posterior pole with NIR-R. NIR-AF revealed high fluorescent regions of similar sizes at fundus locations identical to those shown by NIR-R. In one case, hypofluorescent regions were shown by indocyanine green angiography in the bright fluorescent region shown by NIR-AF. The other two cases showed no abnormality under conventional fundus examination or fluorescein angiography. OCT images crossing the bright patchy region showed irregular hyper-reflectivity in the choroid in two cases and hyporeflectivity in one case.Conclusions: NIR-AF demonstrated that dense melanin was included in the choroidal nodules of neurofibromatosis type 1. The choroidal nodules showed hyper- or hyporeflectivity in the choroid on OCT, which did not affect the retinal structure.Keywords: near-infrared fundus autofluorescence, neurofibromatosis type 1, choroidal nodule, melaninUeda-Consolvo TMiyakoshi AOzaki HHouki SHayashi ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1191-1194 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ueda-Consolvo T Miyakoshi A Ozaki H Houki S Hayashi A Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
description	Tomoko Ueda-Consolvo, Akio Miyakoshi, Hironori Ozaki, Satoshi Houki, Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanPurpose: To report a series of three cases of neurofibromatosis type 1 examined by near-infrared fundus autofluorescence (NIR-AF) with a scanning laser ophthalmoscope and spectral-domain optical coherence tomography (OCT) to show the characteristics of choroidal abnormalities.Methods: Retrospective case series. Six eyes of three patients were examined by conventional fundus examinations, near-infrared monochromatic light reflectance (NIR-R) and NIR-AF, OCT, fluorescein angiography, and indocyanine green angiography.Results: All eyes showed multiple bright patchy regions in the choroid of the posterior pole with NIR-R. NIR-AF revealed high fluorescent regions of similar sizes at fundus locations identical to those shown by NIR-R. In one case, hypofluorescent regions were shown by indocyanine green angiography in the bright fluorescent region shown by NIR-AF. The other two cases showed no abnormality under conventional fundus examination or fluorescein angiography. OCT images crossing the bright patchy region showed irregular hyper-reflectivity in the choroid in two cases and hyporeflectivity in one case.Conclusions: NIR-AF demonstrated that dense melanin was included in the choroidal nodules of neurofibromatosis type 1. The choroidal nodules showed hyper- or hyporeflectivity in the choroid on OCT, which did not affect the retinal structure.Keywords: near-infrared fundus autofluorescence, neurofibromatosis type 1, choroidal nodule, melanin
format	article
author	Ueda-Consolvo T Miyakoshi A Ozaki H Houki S Hayashi A
author_facet	Ueda-Consolvo T Miyakoshi A Ozaki H Houki S Hayashi A
author_sort	Ueda-Consolvo T
title	Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
title_short	Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
title_full	Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
title_fullStr	Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
title_full_unstemmed	Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
title_sort	near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/28e35e034b4b454dafd94fb7e4bb7696
work_keys_str_mv	AT uedaconsolvot nearinfraredfundusautofluorescencevisualizedmelanininthechoroidalabnormalitiesofneurofibromatosistype1 AT miyakoshia nearinfraredfundusautofluorescencevisualizedmelanininthechoroidalabnormalitiesofneurofibromatosistype1 AT ozakih nearinfraredfundusautofluorescencevisualizedmelanininthechoroidalabnormalitiesofneurofibromatosistype1 AT houkis nearinfraredfundusautofluorescencevisualizedmelanininthechoroidalabnormalitiesofneurofibromatosistype1 AT hayashia nearinfraredfundusautofluorescencevisualizedmelanininthechoroidalabnormalitiesofneurofibromatosistype1
_version_	1718400819107201024

Near-infrared fundus autofluorescence-visualized melanin in the choroidal abnormalities of neurofibromatosis type 1

Ejemplares similares