Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life

Asthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-world study investigated whether phenotyping patients with asthma...

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Autores principales:	Fabio Luigi Massimo Ricciardolo, Andrea Elio Sprio, Andrea Baroso, Fabio Gallo, Elisa Riccardi, Francesca Bertolini, Vitina Carriero, Elisa Arrigo, Giorgio Ciprandi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	asthma inflammation asthma phenotypes real-world clinical practice T2 low Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/28e396e52d32412b85e279670b83542d
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spelling	oai:doaj.org-article:28e396e52d32412b85e279670b83542d2021-11-25T16:50:48ZCharacterization of T2-Low and T2-High Asthma Phenotypes in Real-Life10.3390/biomedicines91116842227-9059https://doaj.org/article/28e396e52d32412b85e279670b83542d2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1684https://doaj.org/toc/2227-9059Asthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-world study investigated whether phenotyping patients with asthma using non-invasive parameters could be feasible to characterize the T2-low and T2-high asthma phenotypes in clinical practice. This cross-sectional observational study involved asthmatic outpatients (<i>n</i> = 503) referring to the Severe Asthma Centre of the San Luigi Gonzaga University Hospital. Participants were stratified according to the patterns of T2 inflammation and atopic sensitization. Among outpatients, 98 (19.5%) patients had T2-low asthma, 127 (25.2%) T2-high non-allergic, and 278 (55.3%) had T2-high allergic phenotype. In comparison to T2-low, allergic patients were younger (OR 0.945, <i>p</i> < 0.001) and thinner (OR 0.913, <i>p</i> < 0.001), had lower smoke exposure (OR 0.975, <i>p</i> < 0.001) and RV/TLC% (OR 0.950, <i>p</i> < 0.001), higher prevalence of asthma severity grade 5 (OR 2.236, <i>p</i> < 0.05), more frequent rhinitis (OR 3.491, <i>p</i> < 0.001) and chronic rhinosinusitis with (OR 2.650, <i>p</i> < 0.001) or without (OR 1.919, <i>p</i> < 0.05) nasal polyps, but less common arterial hypertension (OR 0.331, <i>p</i> < 0.001). T2-high non-allergic patients had intermediate characteristics. Non-invasive phenotyping of asthmatic patients is possible in clinical practice. Identifying characteristics in the three main asthma phenotypes could pave the way for further investigations on useful biomarkers for precision medicine.Fabio Luigi Massimo RicciardoloAndrea Elio SprioAndrea BarosoFabio GalloElisa RiccardiFrancesca BertoliniVitina CarrieroElisa ArrigoGiorgio CiprandiMDPI AGarticleasthmainflammationasthma phenotypesreal-worldclinical practiceT2 lowBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1684, p 1684 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	asthma inflammation asthma phenotypes real-world clinical practice T2 low Biology (General) QH301-705.5
spellingShingle	asthma inflammation asthma phenotypes real-world clinical practice T2 low Biology (General) QH301-705.5 Fabio Luigi Massimo Ricciardolo Andrea Elio Sprio Andrea Baroso Fabio Gallo Elisa Riccardi Francesca Bertolini Vitina Carriero Elisa Arrigo Giorgio Ciprandi Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
description	Asthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-world study investigated whether phenotyping patients with asthma using non-invasive parameters could be feasible to characterize the T2-low and T2-high asthma phenotypes in clinical practice. This cross-sectional observational study involved asthmatic outpatients (<i>n</i> = 503) referring to the Severe Asthma Centre of the San Luigi Gonzaga University Hospital. Participants were stratified according to the patterns of T2 inflammation and atopic sensitization. Among outpatients, 98 (19.5%) patients had T2-low asthma, 127 (25.2%) T2-high non-allergic, and 278 (55.3%) had T2-high allergic phenotype. In comparison to T2-low, allergic patients were younger (OR 0.945, <i>p</i> < 0.001) and thinner (OR 0.913, <i>p</i> < 0.001), had lower smoke exposure (OR 0.975, <i>p</i> < 0.001) and RV/TLC% (OR 0.950, <i>p</i> < 0.001), higher prevalence of asthma severity grade 5 (OR 2.236, <i>p</i> < 0.05), more frequent rhinitis (OR 3.491, <i>p</i> < 0.001) and chronic rhinosinusitis with (OR 2.650, <i>p</i> < 0.001) or without (OR 1.919, <i>p</i> < 0.05) nasal polyps, but less common arterial hypertension (OR 0.331, <i>p</i> < 0.001). T2-high non-allergic patients had intermediate characteristics. Non-invasive phenotyping of asthmatic patients is possible in clinical practice. Identifying characteristics in the three main asthma phenotypes could pave the way for further investigations on useful biomarkers for precision medicine.
format	article
author	Fabio Luigi Massimo Ricciardolo Andrea Elio Sprio Andrea Baroso Fabio Gallo Elisa Riccardi Francesca Bertolini Vitina Carriero Elisa Arrigo Giorgio Ciprandi
author_facet	Fabio Luigi Massimo Ricciardolo Andrea Elio Sprio Andrea Baroso Fabio Gallo Elisa Riccardi Francesca Bertolini Vitina Carriero Elisa Arrigo Giorgio Ciprandi
author_sort	Fabio Luigi Massimo Ricciardolo
title	Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
title_short	Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
title_full	Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
title_fullStr	Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
title_full_unstemmed	Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
title_sort	characterization of t2-low and t2-high asthma phenotypes in real-life
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/28e396e52d32412b85e279670b83542d
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Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life

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