Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

Understanding the mechanisms that lead to lung adenocarcinoma metastasis is important for identifying new therapeutics. Here, the authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics.

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Autores principales:	Nayoung Kim, Hong Kwan Kim, Kyungjong Lee, Yourae Hong, Jong Ho Cho, Jung Won Choi, Jung-Il Lee, Yeon-Lim Suh, Bo Mi Ku, Hye Hyeon Eum, Soyean Choi, Yoon-La Choi, Je-Gun Joung, Woong-Yang Park, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Keunchil Park, Myung-Ju Ahn, Hae-Ock Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28e39cc8f39944739a58a123f53b6a98
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spelling	oai:doaj.org-article:28e39cc8f39944739a58a123f53b6a982021-12-02T17:06:32ZSingle-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma10.1038/s41467-020-16164-12041-1723https://doaj.org/article/28e39cc8f39944739a58a123f53b6a982020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16164-1https://doaj.org/toc/2041-1723Understanding the mechanisms that lead to lung adenocarcinoma metastasis is important for identifying new therapeutics. Here, the authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics.Nayoung KimHong Kwan KimKyungjong LeeYourae HongJong Ho ChoJung Won ChoiJung-Il LeeYeon-Lim SuhBo Mi KuHye Hyeon EumSoyean ChoiYoon-La ChoiJe-Gun JoungWoong-Yang ParkHyun Ae JungJong-Mu SunSe-Hoon LeeJin Seok AhnKeunchil ParkMyung-Ju AhnHae-Ock LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nayoung Kim Hong Kwan Kim Kyungjong Lee Yourae Hong Jong Ho Cho Jung Won Choi Jung-Il Lee Yeon-Lim Suh Bo Mi Ku Hye Hyeon Eum Soyean Choi Yoon-La Choi Je-Gun Joung Woong-Yang Park Hyun Ae Jung Jong-Mu Sun Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn Hae-Ock Lee Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
description	Understanding the mechanisms that lead to lung adenocarcinoma metastasis is important for identifying new therapeutics. Here, the authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics.
format	article
author	Nayoung Kim Hong Kwan Kim Kyungjong Lee Yourae Hong Jong Ho Cho Jung Won Choi Jung-Il Lee Yeon-Lim Suh Bo Mi Ku Hye Hyeon Eum Soyean Choi Yoon-La Choi Je-Gun Joung Woong-Yang Park Hyun Ae Jung Jong-Mu Sun Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn Hae-Ock Lee
author_facet	Nayoung Kim Hong Kwan Kim Kyungjong Lee Yourae Hong Jong Ho Cho Jung Won Choi Jung-Il Lee Yeon-Lim Suh Bo Mi Ku Hye Hyeon Eum Soyean Choi Yoon-La Choi Je-Gun Joung Woong-Yang Park Hyun Ae Jung Jong-Mu Sun Se-Hoon Lee Jin Seok Ahn Keunchil Park Myung-Ju Ahn Hae-Ock Lee
author_sort	Nayoung Kim
title	Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
title_short	Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
title_full	Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
title_fullStr	Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
title_full_unstemmed	Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
title_sort	single-cell rna sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/28e39cc8f39944739a58a123f53b6a98
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Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

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